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This study reveals how RGS (show PITX2 ELISA Kits) proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
this study shows that Galphai2 controls arrest in response to chemokine (show CCL1 ELISA Kits) stimulation of neutrophils
In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning.
Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
RGS (show PITX2 ELISA Kits) proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM (show REM1 ELISA Kits) sleep
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A ELISA Kits)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 ELISA Kits) alpha subunits Galphai2, Galphai3 (show GNAI3 ELISA Kits), and Galphaq (show GNAQ ELISA Kits).
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3 (show GNAI3 ELISA Kits), with no evidence for functional coupling to Galphagust.
Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.
Galpha (show SUCLG1 ELISA Kits)(i2) activates the TRPC4 (show TRPC4 ELISA Kits) channel by direct binding.
Changes in ion selectivity and pore dilation of the TRPC4 (show TRPC4 ELISA Kits) channel elicited by the Galphai2 subunit, were studied.
Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C (show PKC ELISA Kits) - and histone deacetylase (show HDAC1 ELISA Kits) -dependent manner
These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (show CACNA1A ELISA Kits) Ca(2 (show CA2 ELISA Kits)+) channels
The ubiquitination of Galphai2 and Galphaq (show GNAQ ELISA Kits) is suppressed by expression of Ric-8A (show RIC8A ELISA Kits). The suppression likely requires Ric-8A (show RIC8A ELISA Kits) interaction with these Galpha (show SUCLG1 ELISA Kits) proteins; the C-terminal truncation of Galphaq (show GNAQ ELISA Kits) and Galphai2 completely abrogates their interaction with Ric-8A (show RIC8A ELISA Kits).
Gialpha2 plays an essential role in OXT (show OXT ELISA Kits) and EGF (show EGF ELISA Kits) signaling to induce prostate cancer cell migration.
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha (show SUCLG1 ELISA Kits)(i2) for degradation through ubiquitination
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 2
, guanine nucleotide-binding protein G(i) subunit alpha-2
, Gi2 protein alpha-subunit
, GTP-binding regulatory protein Gi alpha-2 chain
, guanine nucleotide-binding protein G(i), alpha-2 subunit
, guanine nucleotide-binding regulatory protein alpha inhibitory subunit
, Gi-alpha-2 protein
, guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
, guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
, G alpha inhibitory type 2 (a)
, G alpha inhibitory type 2 (b)
, GTP-binding protein (G-alpha-i2)
, guanine nucleotide binding protein (G protein), alpha inhibiting 2
, guanine nucleotide binding protein, alpha inhibiting 3
, Galpha i2a
, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
, guanine nucleotide-binding protein Gi2 alpha-subunit