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Mutant p53 (show TP53 Proteins) and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death.
The polymorphism rs12266644 of PAX2 might be a risk factor for mullerian duct anomalies in Chinese Han females
PAX2, PAX8 (show PAX8 Proteins), CDX2 (show CDX2 Proteins) immunostains was preformed to the TMA slides.
we demonstrated that miR (show MLXIP Proteins)-497 is decreased in human ovarian cancer tissues and cells, and acts as a tumor suppressor. We also confirmed PAX2 is a target gene of miR (show MLXIP Proteins)-497
Vimentin (show VIM Proteins), Nestin (show NES Proteins) and WT1 (show WT1 Proteins). Sox2 (show SOX2 Proteins) was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE (show ENO2 Proteins).
PAX2 and PAX5 (show PAX5 Proteins) are useful biomarker in the differential diagnosis of lung cancer
a substantial minority of solitary fibrous tumors express nuclear PAX8 (show PAX8 Proteins) and PAX2
PAX2 gene silencing can significantly inhibit the process of epithelial-mesenchymal transition (EMT (show ITK Proteins)) of renal tubular cells in rats with advanced fibrosis.
The results of this study identify several new mutations of PAX2, and sequence variants in four additional genes, including a novel potentially pathogenic mutation in KIF26B, which may play a role in the pathogenesis of Renal Coloboma Syndrome.
data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 and PAX5 (show PAX5 Proteins)
Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program.
Pax2-regulated ISL1 (show ISL1 Proteins) overexpression increases the embryonic ISL1 (show ISL1 Proteins)(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
PAX2 may not be a classical oncogene (show RAB1A Proteins) or tumor suppressor but instead can act in either role by differential regulation of COX2 and/or HTRA1 (show HTRA1 Proteins).
Dicer (show DICER1 Proteins) ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (show Klra7 Proteins))-Pax2 protein knockout embryos.
a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
the role of Pax2 protein levels in determining correct renal architecture and cell fate in urogenital development.
cross-talk between p53 (show TP53 Proteins) and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment
Pax2a and Pax8 (show PAX8 Proteins) regulate cell differentiation during sensory placode formation
Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development
pax8 (show PAX8 Proteins) works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Proteins), a necessary step for further otic development
wnt1 (show WNT1 Proteins) and wnt10b (show WNT10B Proteins) are required to maintain threshold levels of Pax2.1 and Fgf8 (show FGF8 Proteins) at the midbrain-hindbrain boundary.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Pax2a and Pax8 (show PAX8 Proteins) are the main effectors downstream of Fgf signals in ear formation
pax8 (show PAX8 Proteins) is initially required for normal otic induction, and subsequently pax8 (show PAX8 Proteins), pax2a and pax2b act redundantly to maintain otic fate
Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
paired box 2
, paired box gene 2
, paired box protein Pax-2
, paired-box protein Pax-2
, paired-box containing protein Pax-2
, paired box homeotic gene 2
, optic disc coloboma
, no isthmus protein
, paired box gene 2.1
, paired box homeotic gene 2a
, paired box protein Pax-2a