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cadherin-7 plays an important role in the normal development of the zebrafish notochord.
Our results support CDH7 to be a risk factor of major depressive disorder in the Han Chinese population
Cadherin-7 interacts with melanoma inhibitory activity protein (show MIA ELISA Kits) and negatively modulates melanoma cell migration.
During oncogenesis, cadherin-7, N-cad and E-cad could be used as an efficient marker set for melanoma.
This gene is a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures. Alternative splicing in the 5' UTR of this gene yields variant transcripts encoding the same protein.
, cadherin-7 type II