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CD7 chimeric antigen receptor T cells have robust activity against T-cell malignancies in vitro and in vivo.
Data indicate the tissue ligand SECTM1A (Secreted and transmembrane1A) as an alternative CD7 ligand.
Data demonstrate collaborative roles for both CD7 and CD28 (show CD28 Proteins) in determination of number and function of CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+ T regulatory cells in the thymus and peripheral immune sites and in the development of spontaneous thyroiditis.
differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor
The regulation of CD7 gene expression through NF-kappaB (show NFKB1 Proteins) activation induced by TCR/CD28 (show CD28 Proteins) might have significant implications for T-cell homeostasis.
Molecular mimicry of murine CD7 with HSP-60 (show HSPD1 Proteins) is demonstrated; CD7 may regulate HSP-60 (show HSPD1 Proteins) expression in mouse small intestine.
in acute myeloid leukemia (show BCL11A Proteins) patients the association of CD7 (show CDK7 Proteins) positivity and FLT3 (show FLT3 Proteins) positivity was found to be significant
Data show that CD7 (show CDK7 Proteins) promotes extramedullary involvement of the B-ALL line Tanoue in an integrin beta2-dependent manner.
We showed that the CADM1 (show CADM1 Proteins) versus CD7 (show CDK7 Proteins) plot is capable of discriminating clonally expanding HTLV-I-infected cells in indolent and acute-type T-cell leukemia-lymphomas and in asymptomatic carriers
CD7 (show CDK7 Proteins) is present on monocytes and tumor macrophages and its ligand, SECTM1 (show SECTM1 Proteins), is frequently expressed in corresponding melanoma tissues
SECTM1 (show SECTM1 Proteins) secreted from bone marrow stromal cells may interact with CD7 (show CDK7 Proteins) to influence GM-CSF (show CSF2 Proteins) expression in leukemic cells.
epigenetic down-regulation of CD7 (show CDK7 Proteins) is associated with acute myeloid leukemia (show BCL11A Proteins).
CD7 (show CDK7 Proteins) loss in aggressive natural killer-cell leukemia; a useful diagnostic marker
low expression in T-cell lymphomas due to Twist2 (show TWIST2 Proteins)-mediated suppression of promoter activity; enhanced by histone deacetylase (show HDAC1 Proteins) inhibitors
These findings indicate a link between epigenetic modifications and CD7 (show CDK7 Proteins) expression in primitive chronic myeloid leukemia (show BCL11A Proteins) cells.
CD7 (show CDK7 Proteins) expression in hematopoitic cells denotes commitment to B (show TDO2 Proteins)-cell and natural killer cells lineages.
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.
T-cell antigen CD7
, CD7 antigen (p41)
, T-cell leukemia antigen
, T-cell surface antigen Leu-9
, p41 protein
, Thy-1 protein
, Thymus cell surface antigen
, thy-1 antigen
, thy-1 glycoprotein
, thy-1 membrane glycoprotein
, thymus cell antigen 1, theta