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Browse our anti-Plakophilin 2 (PKP2) Antibodies

Full name:
anti-Plakophilin 2 Antibodies (PKP2)
On www.antibodies-online.com are 72 Plakophilin 2 (PKP2) Antibodies from 21 different suppliers available. Additionally we are shipping Plakophilin 2 Kits (18) and and many more products for this protein. A total of 99 Plakophilin 2 products are currently listed.
Synonyms:
1200008D14Rik, 1200012P04Rik, AA516617, ARVD9, Pkp2l
list all antibodies Gene Name GeneID UniProt
PKP2 5318 Q99959
PKP2 67451  
PKP2 287925  

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Most Popular Reactivities for anti-Plakophilin 2 (PKP2) Antibodies

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anti-Human Plakophilin 2 Antibodies:

anti-Mouse (Murine) Plakophilin 2 Antibodies:

anti-Rat (Rattus) Plakophilin 2 Antibodies:

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Top referenced anti-Plakophilin 2 Antibodies

  1. Cow (Bovine) Monoclonal Plakophilin 2 Primary Antibody for IHC (fro), IHC (p) - ABIN112248 : Akat, Mennel, Kremer, Gassler, Bleck, Kartenbeck: Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. in Acta neuropathologica 2003 (PubMed)
    Show all 7 references for ABIN112248

  2. Human Polyclonal Plakophilin 2 Primary Antibody for EIA, IHC (p) - ABIN954172 : Fressart, Duthoit, Donal, Probst, Deharo, Chevalier, Klug, Dubourg, Delacretaz, Cosnay, Scanu, Extramiana, Keller, Hidden-Lucet, Simon, Bessirard, Roux-Buisson, Hebert, Azarine, Casset-Senon, Rouzet, Lecarpentier, Fontaine, Coirault, Frank, Hainque, Charr: Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice. in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2010 (PubMed)
    Show all 4 references for ABIN954172

  3. Human Polyclonal Plakophilin 2 Primary Antibody for ELISA, WB - ABIN1535176 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)
    Show all 2 references for ABIN1535176

  4. Human Polyclonal Plakophilin 2 Primary Antibody for IF (p), IHC (p) - ABIN1386389 : Akdis, Medeiros-Domingo, Gaertner-Rommel, Kast, Enseleit, Bode, Klingel, Kandolf, Renois, Andreoletti, Akdis, Milting, Lüscher, Brunckhorst, Saguner, Duru: Myocardial expression profiles of candidate molecules in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia compared to those with dilated cardiomyopathy and healthy controls. in Heart rhythm 2016 (PubMed)

  5. Mouse (Murine) Polyclonal Plakophilin 2 Primary Antibody for ELISA, WB - ABIN4345997 : Christensen, Benn, Tybjaerg-Hansen, Haunso, Svendsen: Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients--disease-causing or innocent bystanders? in Cardiology 2010 (PubMed)

  6. Human Monoclonal Plakophilin 2 Primary Antibody for IF, IP - ABIN968178 : Mertens, Kuhn, Franke: Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. in The Journal of cell biology 1997 (PubMed)

  7. Mouse (Murine) Monoclonal Plakophilin 2 Primary Antibody for IHC (p), IP - ABIN1169700 : Sobolik-Delmaire, Reddy, Pashaj, Roberts, Wahl: Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. in The Journal of investigative dermatology 2010 (PubMed)

  8. Human Polyclonal Plakophilin 2 Primary Antibody for WB - ABIN2786784 : Bass-Zubek, Hobbs, Amargo, Garcia, Hsieh, Chen, Wahl, Denning, Green: Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. in The Journal of cell biology 2008 (PubMed)

More Antibodies against Plakophilin 2 Interaction Partners

Human Plakophilin 2 (PKP2) interaction partners

  1. Results show the involvement of plakophilin 2 protein (PKP2) in two siblings with severe cardiomyopathy with ventricular non compaction.

  2. PKP2 c.419C>T did not associate with heart failure, arrhythmias, or premature death, with ARVC or HCM/DCM, or with effects in vitro, suggesting that this is not a disease-causing variant.

  3. Extreme variability in clinical penetrance for a splice-site PKP2 mutation was found in a Bangladeshi family. Some family members were affected by arrhythmogenic right ventricular cardiomyopathy, and some are asymptomatic.

  4. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (show DSC2 Antibodies)), plakophilin 2 (PKP2), and plakophilin 3 (PKP3 (show PKP3 Antibodies)) are involved in desmosome formation in epithelial cells; DSC2 (show DSC2 Antibodies) participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 Antibodies)).

  5. PKP2 regulates Wnt (show WNT2 Antibodies) activity during adipogenic and cardiomyogenic differentiation in arrhythmogenic right ventricular cardiomyopathy.

  6. A heterozygous pathogenic variant in the plakophilin-2 (c.2392A>G, p.T798A) gene was found in an arrhythmogenic LV cardiomyopathy patient and his deceased mother who had had arrhythmogenic cardiomyopathy affecting both ventricles.

  7. Six variants of uncertain clinical significance in the PKP2, JUP (show JUP Antibodies), and DSG2 (show DSG2 Antibodies) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Antibodies)/C-related pathogenic splice site mutations.

  8. Exercise test is valuable for the diagnosis of ARVC in patients with PKP2 gene mutation.

  9. Case Report: PKP2/DSP (show DSP Antibodies) mutations in patient with Brugada syndrome and ventricular tachycardia.

  10. The introduction of the PKP2 R735X mutation into mice resulted in an exercise-dependent arrhythmogenic right ventricular cardiomyopathy.

Mouse (Murine) Plakophilin 2 (PKP2) interaction partners

  1. PKP2 deficiency leads to suppression of the E2F1 (show E2F1 Antibodies) pathway and hypermethylation of CPG sites at miR (show MLXIP Antibodies)-184 promoter.

  2. Plakophilin-2 loss promotes TGF-beta1 (show TGFB1 Antibodies)/p38 MAPK (show MAPK14 Antibodies)-dependent fibrotic gene expression in cardiomyocytes.

  3. Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.

  4. PKP2 haploinsufficiency leads to I(Na) deficit in murine hearts which may contribute to generation and/or maintenance of arrhythmias.

  5. plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart

  6. By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells.

Cow (Bovine) Plakophilin 2 (PKP2) interaction partners

  1. PKP2 increased connexin 43 (show GJA1 Antibodies), a gap junction protein, while its knockdown inhibited embryo implantation in mice.

Plakophilin 2 (PKP2) Antigen Profile

Antigen Summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Alternative names and synonyms associated with Plakophilin 2 (PKP2)

  • plakophilin 2 (PKP2) antibody
  • plakophilin 2 (Pkp2) antibody
  • plakophilin 2 (LOC100347738) antibody
  • 1200008D14Rik antibody
  • 1200012P04Rik antibody
  • AA516617 antibody
  • ARVD9 antibody
  • Pkp2l antibody

Protein level used designations for anti-Plakophilin 2 (PKP2) Antibodies

plakophilin-2

GENE ID SPECIES
100070065 Equus caballus
5318 Homo sapiens
67451 Mus musculus
287925 Rattus norvegicus
537784 Bos taurus
486613 Canis lupus familiaris
100347738 Oryctolagus cuniculus
100728409 Cavia porcellus
100526169 Sus scrofa
418130 Gallus gallus
101104733 Ovis aries
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