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Browse our CDK5 (CDK5) ELISA Kits

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Cyclin-Dependent Kinase 5 ELISA Kits (CDK5)
On are 50 Cyclin-Dependent Kinase 5 (CDK5) ELISA Kits from 11 different suppliers available. Additionally we are shipping CDK5 Antibodies (219) and CDK5 Proteins (14) and many more products for this protein. A total of 298 CDK5 products are currently listed.
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604

More ELISA Kits for CDK5 Interaction Partners

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. A novel role of STAT3 (show STAT3 ELISA Kits)/miR (show MLXIP ELISA Kits)-21 axis and CDK5/CDK5R1 (p35 (show CDK5R1 ELISA Kits)) in metastasis of head and neck squamous cell carcinoma.

  2. A cyclin I (show CCNI ELISA Kits)-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.

  3. These results for the first time demonstrate a role of Cdk5/p35 (show ANXA1 ELISA Kits) in the regulation of cell cycle progression modulated by TGF-beta1 (show TGFB1 ELISA Kits).

  4. Data show that cyclin-dependent kinase 5 (Cdk5) could phosphorylate the adjacent S1627 in the leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 ELISA Kits)) R1628P mutant.

  5. These p35 (show ANXA1 ELISA Kits) mutations are unlikely to cause mental retardation.

  6. These data identify a novel oncogenic mechanism where CDK5 activation induces CRMP2A (show DPYSL2 ELISA Kits) phosphorylation in the nuclei of tumour cells

  7. Increased expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients.

  8. Results reveal a link between p25 (show LCN2 ELISA Kits) and BACE1 (show BACE ELISA Kits) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 activation by p25 (show LCN2 ELISA Kits) accelerates AD pathogenesis by enhancing BACE1 (show BACE ELISA Kits) activity via phosphorylation.

  9. Data indicate that combining the CDK (show CDK4 ELISA Kits) inhibitor dinaciclib with the pan-AKT (show AKT1 ELISA Kits) inhibitor MK-2206 showed promising therapeutic results in pancreatic cancer murine model.

  10. Functional inhibition of CDK5 using roscovitine and siRNA markedly suppressed the proliferation of A549 cells and resulted in a reduced tumor mass in vivo.

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The transiently active CDK5-p35 (show CDK5R1 ELISA Kits) complexes limited the LPS (show TLR4 ELISA Kits)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 ELISA Kits))

  2. this finding highlights a central role for Cdk5 in immune checkpoint regulation by tumor cells.

  3. Cdk5 (cyclin-dependent kinase 5) requires p35 (show CDK5R1 ELISA Kits) regulatory subunit (Cdk5r1 (show CDK5R1 ELISA Kits)) for activation; data suggest Cdk5r1 (show CDK5R1 ELISA Kits) stability regulates Cdk5 activity in neurons; Cdk5r1 (show CDK5R1 ELISA Kits) is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  4. The findings of this study suggest that CDK5-depleted astrocytes act as a neuroprotective trophic source in a Rac1-dependent manner.

  5. phosphorylation of coronin 1 on Thr (show TRH ELISA Kits)(418/424) by cyclin-dependent kinase (show CDK1 ELISA Kits) (CDK) 5 activity was responsible for coronin 1-Galphas (show GNAS ELISA Kits) association and the modulation of cAMP production

  6. Nitric oxide -induced reduction in Cdk5 activity is mediated by S-nitrosylation of p35 (show CDK5R1 ELISA Kits), resulting in its ubiquitination and degradation by the E3 ligase PJA2 (show PJA2 ELISA Kits).

  7. conditional deletion of CDK5 significantly attenuates DRP1 (show CRMP1 ELISA Kits) phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.

  8. Cdk5 regulates lymphatic vessel formation and function via phosphorylation of Foxc2 (show FOXC2 ELISA Kits). Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation.

  9. Acute stress (AS) caused a biphasic effect on CDK5 activity, initially reducing but increasing afterwards in prefrontal cortex and hippocampus, whereas chronic unpredictable stress (CS) strongly increased it in these brain areas.

  10. Cdk5 modulates gene expression during T-cell activation by impairing the repression of gene transcription by histone deacetylase 1 (HDAC1 (show HDAC1 ELISA Kits)) through specific phosphorylation of the mSin3a protein at serine residue 861.

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (show PPP1CA ELISA Kits) is a downstream target of the NGF (show NGFB ELISA Kits)/Egr-1 (show EGR1 ELISA Kits)/Cdk5 pathway during NGF (show NGFB ELISA Kits)-induced differentiation of PC12 cells and suggest that PP1 (show PPYR1 ELISA Kits) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (show SIRT1 ELISA Kits) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (show CDK5R1 ELISA Kits) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The CDK5 phosphorylates MEKK1 (show MAP3K1 ELISA Kits), and together, they activate the JNK (show MAPK8 ELISA Kits) pathway for apoptosis.

  2. The data of this study demonstrated that Cdk5/p35 (show RPLP0 ELISA Kits) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  3. Therefore, we propose that Abl and p35/p25 (show CDK5R1 ELISA Kits) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  4. Cdk5/p35 (show RPLP0 ELISA Kits) did not have major effects on tau toxicity or phosphorylation.

  5. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 ELISA Kits) and Dpysl3 (show DPYSL3 ELISA Kits) by Cdk5 and DYRK2 (show DYRK2 ELISA Kits) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  2. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  3. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  4. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 Antigen Profile

Antigen Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5) Elisa Kit
  • cyclin-dependent kinase 5 (Cdk5) Elisa Kit
  • Cyclin-dependent kinase 5 (Cdk5) Elisa Kit
  • cyclin-dependent kinase 5 (cdk5) Elisa Kit
  • cyclin-dependent kinase 5 (LOC100352775) Elisa Kit
  • cyclin-dependent protein kinase 5 (cdk5) Elisa Kit
  • AW048668 Elisa Kit
  • cdk5 Elisa Kit
  • CG8203 Elisa Kit
  • Crk6 Elisa Kit
  • DmCdk5 Elisa Kit
  • Dmel\\CG8203 Elisa Kit
  • PSSALRE Elisa Kit
  • zgc:101604 Elisa Kit

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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