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The differences in p18(INK4c)and p57(Kip2 (show CDKN1C ELISA Kits))activities in chronic myeloid leukemia (show BCL11A ELISA Kits) and normal stem cells suggest a different cell cycle regulation.
Our study suggests that p18 is a limiting factor for the noncanonical HSC (show FUT1 ELISA Kits) differentiation path in lymphoid lineages.
CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia (show PML ELISA Kits).
DNA methyltransferase 3A (show DNMT3A ELISA Kits) promotes cell proliferation by silencing CDK (show CDK4 ELISA Kits) inhibitor p18INK4C in gastric carcinogenesis
Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 (show CDKN1A ELISA Kits) facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors).
this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1 (show CDKN1B ELISA Kits)), its phosphorylated form, p-p27 (show PAK2 ELISA Kits)(S10 (show L1CAM ELISA Kits)), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.
in 85 sporadic parathyroid adenomas, study identified alterations in 5 adenomas: 2 contained heterozygous changes in CDKN1A, 1 germline and 1 of undetermined germline status; 1 had a CDKN2B (show CDKN2B ELISA Kits) germline alteration, accompanied by loss of the normal allele in the tumor (LOH); 2 had variants of CDKN2C, 1 somatic and 1 germline with LOH
Mutations in CDKN2C is associated with sporadic parathyroid adenoma.
Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool.
up-regulated HULC promotes proliferation of hepatoma cells through suppressing p18
CD4 (show CD4 ELISA Kits)+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals.
p18 represents a potent and specific target for enhancing the self-renewal property of HSC (show FUT1 ELISA Kits), as demonstrated the effect of inhibitors
p18 may play protective roles and may be associated with or partially account for the cytoprotective effects of HO-1 (show HMOX1 ELISA Kits) in cisplatin-induced acute kidney injury.
Cdk4 (show CDK4 ELISA Kits) and Cdk6 (show CDK6 ELISA Kits) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 ELISA Kits) in sequestering INK4 proteins away from Cdk4 (show CDK4 ELISA Kits).
Gata3 (show GATA3 ELISA Kits)/Ruvbl2 (show RUVBL2 ELISA Kits) complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
deletion of P18 results in a deacreased proliferation of hematopoietic progenitor cells (HPCs) suggesting a positive role for P18 on HPCs in vivo
A p18 -74 C/T mutation is the leading causal variant for the cell expansion that characterizes NZB and NZM2410 lupus-prone mouse strains.
This study demonstrated the predominant expression MEN1 (show MEN1 ELISA Kits)-related genes, particularly MLL (show MLL ELISA Kits) and p27 (show CDKN1B ELISA Kits), in the endocrine organs, and a tissue-specific haploinsuffiency of MLL (show MLL ELISA Kits) may lead to a decrease in levels of p27 (show CDKN1B ELISA Kits) and p18 mRNAs in endocrine organs.
Cdkn2c plays a critical role in B1a cell self-renewal and its impaired expression leads to an accumulation of these cells with high autoreactive potential.
define the first physiologic function for Noxa (show PMAIP1 ELISA Kits) and suggest that by repressing Noxa (show PMAIP1 ELISA Kits), induction of G arrest by p18INK4c bypasses a homeostatic cell-cycle checkpoint in intermediate plasma cells (iPCs) for PC differentiation
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
, cyclin-dependent kinase 4 inhibitor C
, CDK6 inhibitor p18
, cyclin-dependent inhibitor
, cyclin-dependent kinase 6 inhibitor p18
, cyclin-dependent kinase 6 inhibitor