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anti-Mouse (Murine) PDE4D Antibodies:
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Human Polyclonal PDE4D Primary Antibody for ELISA, WB - ABIN185530
Houslay: The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target. in Molecular pharmacology 2005
Show all 3 Pubmed References
The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D
In vivo knockdown of (show FN1 Antibodies) PDE4D5 inhibited inflammation at athero-prone sites (show TWIST1 Antibodies)
Results indicate that the cyclic AMP (show TMPRSS5 Antibodies) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (show TWIST1 Antibodies)) activity adrenal cortex-derived Y-1 cell line.
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 Antibodies) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG Antibodies)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 (show SIK1 Antibodies) serves as a part of a self-regulatory circuit to modulate insulin (show INS Antibodies) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS (show NOS2 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (show DISC1 Antibodies) or ATF4 (show ATF4 Antibodies) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 Antibodies) with the PDE4D9 locus requires ATF4 (show ATF4 Antibodies)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin regulates degradation of phosphodiesterase 3B (show PDE3B Antibodies), in addition to phosphodiesterase 4D.
Beta-arrestin-2 (show ARRB2 Antibodies) scaffolding of phosphodiesterase PDE4D5 to the plasma membrane was required for TRPV1 (show TRPV1 Antibodies) desensitization.
Screening of PRKAR1A (show PRKAR1A Antibodies) and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism
p53 (show TP53 Antibodies) induced the transcription of miR (show MLXIP Antibodies)-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes.
High PDE4D expression is associated with melanoma.
cells on fibronectin (show FN1 Antibodies) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 Antibodies)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population.
RACK1 (show GNB2L1 Antibodies) and beta-arrestin2 (show ARRB2 Antibodies) inhibit the dimerization of PDE4D5.
PDE4D acts to allow cAMP-elevating agents to regulate VECADs' role as a sensor of flow-associated fluid shear stress (FSS)-encoded information in arterial endothelial cells.
PDE4D gene polymorphisms influence the susceptibility for the development of Sudden Sensorineural Hearing Loss in the southern Taiwanese female population.
focus on recent progress made in PDE4D gene research involving genetic and molecular aspects (review)
No association was found between single-nucleotide polymorphisms of ALOX5AP (show ALOX5AP Antibodies) or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population.
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein