PDE4D antibody (C-Term)

Catalog No. ABIN2786831

Product Details anti-PDE4D Antibody

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Horse, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FQFELTLEED GESDTEKDSG SQVEEDTSCS DSKTLCTQDS ESTEIPLDEQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PDE4D. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDE4D

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE4D

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Alternative Name: PDE4D (PDE4D Products)

Background: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Protein Interaction Partner: MAGEA6, GOLGA8F, GOLGA8EP, COIL, TRAF1, ZBTB1, HDGFRP2, BIN1, MAPK1, PIAS4, PRKACA, UBC, SRC, SPTBN1, PIK3CA, LYN, GRB2, FYN, ARRB2, ARRB1, ABL1, APP, PAFAH1B1, CDK2, PPP3R1, PPP3CB, PPP3CA, GSK3B, CSNK1A1, ITSN1, SUMO2, GNB2L1, MDM2, Bub1, PDE4DIP, AKAP6
Protein Size: 507

Molecular Weight: 55 kDa

Gene ID: 5144

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling