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identification and molecular cloning of eight novel transcripts of the human KLK10 gene using 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS), as well as their expression analysis in a wide panel of cell lines, originating from several distinct cancerous and normal tissues
Data suggest that mature KLK9 (kallikrein 9 (show KLK9 Proteins)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (show KLK9 Proteins) appears to extend to KLK10 and midkine (show MDK Proteins); enzyme activity is enhanced by Mg2 (show MUC7 Proteins)+ and Ca2 (show CA2 Proteins)+, but is reversibly attenuated by Zn2+; KLK9 (show KLK9 Proteins) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
KLK10 potentially plays a crucial role in esophageal cancer cell growth.
KLK10 may function as a tumour suppressor by repressing proliferation, enhancing apoptosis and decreasing glucose metabolism in PC3 (show PCSK1 Proteins) cells.
treated and untreated prolactin (show PRL Proteins)-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10
Immunoexpression of KLK10 in the ACTH (show POMC Proteins)-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of non-tumorous pituitaries.
Data indicate that elevated expression of microRNA-375 in head and neck squamous cell carcinoma (HNSCC) cells significantly reduces kallikrein 6 (KLK6 (show KLK6 Proteins)), kallikrein 10 (KLK10), and matrix metalloproteinase 9 (MMP9 (show MMP9 Proteins)) messenger RNA expression.
is the first correlation of oral squamous cell carcinoma with KLK10 rs3745535G>T polymorphisms
KLK6 (show KLK1 Proteins) and KLK10 may be useful markers and potential therapeutic targets in gastroesophageal junction tumors
This study assessed the prognostic utility of human tissue kallikrein (show KLK1 Proteins)-like peptidases 6 and 10 (KLK6 (show KLK1 Proteins) and KLK10) and correlated their expression with histopathological and clinical parameters in gastric cancer.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
kallikrein-related peptidase 10
, kallikrein 10
, breast normal epithelial cell associated serine protease
, normal epithelial cell-specific 1
, protease serine-like 1
, protease, serine-like, 1