Browse our GIPC1 Proteins (GIPC1)

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GIPC PDZ Domain Containing Family, Member 1 Proteins (GIPC1)
On are 10 GIPC PDZ Domain Containing Family, Member 1 (GIPC1) Proteins from 4 different suppliers available. Additionally we are shipping GIPC1 Antibodies (82) and many more products for this protein. A total of 99 GIPC1 products are currently listed.
list all proteins Gene Name GeneID UniProt
GIPC1 10755 O14908
GIPC1 67903 Q9Z0G0
Rat GIPC1 GIPC1 83823 Q9Z254

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GIPC1 Proteins (GIPC1) by Origin

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Top referenced GIPC1 Proteins

  1. Human GIPC1 Protein expressed in Escherichia coli (E. coli) - ABIN667795 : Lee, Ray, How, Blobe: Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for 667795

More Proteins for GIPC1 Interaction Partners

Arabidopsis thaliana GIPC PDZ Domain Containing Family, Member 1 (GIPC1) interaction partners

  1. TIP1;1 and TIP1;2 single or double mutants did not show significant changes in water content or water retention, and showed no sign of early senescence or growth retardation. [TIP1;2]

Zebrafish GIPC PDZ Domain Containing Family, Member 1 (GIPC1) interaction partners

  1. Morpholino knockdown of synectin in zebrafish impaired formation of the thoracic duct, due to selective defects in (show PROX1 Proteins)lymphangiogenic but not angiogenic sprouting.

Xenopus laevis GIPC PDZ Domain Containing Family, Member 1 (GIPC1) interaction partners

  1. Silencing of gipc1 in tadpoles caused lymphatic defects due to an underdevelopment and impaired migration of Prox-1 (show PROX1 Proteins)(+) lymphatic endothelial cells.

  2. Results indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 (show IGF1 Proteins) receptor.

Human GIPC PDZ Domain Containing Family, Member 1 (GIPC1) interaction partners

  1. Upregulated expression of GIPC1 is associated with glioma.

  2. Drd3 (show DRD3 Proteins) palmitoylation acts as a molecular switch for Drd3 (show DRD3 Proteins)-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs.

  3. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.

  4. GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells.

  5. GIPC binds LPA(1 (show LPAR1 Proteins)) and promotes its trafficking from APPL (show APPL1 Proteins)-containing signaling endosomes to EEA1 (show EEA1 Proteins) early endosomes and thus attenuates LPA (show APOA Proteins)-mediated Akt (show AKT1 Proteins) signaling from APPL (show APPL1 Proteins) endosomes.

  6. Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer.

  7. a novel non-Smad (show SMAD1 Proteins) function for endoglin (show ENG Proteins) and GIPC in regulating endothelial cell function during angiogenesis

  8. The placental lectins reduced the binding of IGF-I (show IGF1 Proteins) to IGF-1 (show IGF1 Proteins) receptor in a dose-dependent manner.

  9. Knockdown of ADRM1 (show Adrm1 Proteins) in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK (show RECK Proteins) RNA and protein

  10. GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells

Mouse (Murine) GIPC PDZ Domain Containing Family, Member 1 (GIPC1) interaction partners

  1. Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.

  2. Higher ratios of PSD-95 (show DLG4 Proteins)/GluN2B (show GRIN2B Proteins) and GAIP-interacting protein C (show PROC Proteins)-terminus (GIPC)/GluN2B (show GRIN2B Proteins) were associated with poorer learning index scores across all ages.

  3. findings identify Gipc1 as a new interactor for Vangl2 (show VANGL2 Proteins); show that a myosin VI (show MYO6 Proteins)-Gipc1 protein complex can regulate Vangl2 (show VANGL2 Proteins) traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization

  4. TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3 (show TGFBR3 Proteins)(-/-) mice

  5. GIPC1-MyoGEF (show PLEKHG6 Proteins) complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.

  6. Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling.

  7. Synectin selectively regulates arterial branching morphogenesis.

  8. Results define an important role for the Myo6 (show MYO6 Proteins)-GIPC1 motor complex in presynaptic function and in BDNF (show BDNF Proteins)-TrkB (show NTRK2 Proteins)-mediated synaptic plasticity.

  9. a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ-binding motif drastically reduced GIPC/synectin and myosin VI (show MYO6 Proteins) recruitment to endocytic vesicles

  10. results confirm synectin involvement in FGF2 (show FGF2 Proteins)-dependent signal transduction and provide insights into synectin-dependent gene expression in the endothelium

GIPC1 Protein Profile

Protein Summary

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008

Alternative names and synonyms associated with GIPC1

  • aquaporin TIP1-2 (TIP2)
  • GIPC PDZ domain containing family, member 1 (gipc1)
  • GIPC PDZ domain containing family, member 1 (GIPC1)
  • RGS-GAIP interacting protein GIPC (LOC692815)
  • rgs-gaip interacting protein gipc (AaeL_AAEL012658)
  • rgs-gaip interacting protein gipc (Smp_170870)
  • GIPC PDZ domain containing family, member 1 (Gipc1)
  • C19orf3 protein
  • GAMMA-TIP2 protein
  • Gipc protein
  • GIPC1 protein
  • gipc3 protein
  • GLUT1CBP protein
  • Glut1CIP protein
  • Hs.6454 protein
  • IIP-1 protein
  • kermit protein
  • NIP protein
  • Rgs19 protein
  • Rgs19ip1 protein
  • SEMCAP protein
  • Semcap1 protein
  • SITIP protein
  • SYNECTIIN protein
  • SYNECTIN protein
  • TaxIP2 protein
  • TIP-2 protein
  • TIP1;2 protein
  • tonoplast intrinsic protein 2 protein
  • XGIPC protein

Protein level used designations for GIPC1

GIPC PDZ domain containing family, member 1 , GIPC PDZ domain containing family, member 3 , regulator of G-protein signalling 19 interacting protein 1 , RGS-GAIP interacting protein GIPC , rgs-gaip interacting protein gipc , PDZ domain-containing protein GIPC1 , PDZ domain-containing protein , regulator of G-protein signaling 19-interacting protein 1 , synectin , z-synectin , developmental regulator , GAIP C-terminus-interacting protein , GLUT1 C-terminal binding protein , IGF-1 receptor interacting protein 1 , RGS-GAIP-interacting protein , RGS19-interacting protein 1 , tax interaction protein 2 , SEMCAP-1 , Tax interacting protein, clone 2 , neurophilin1-IP , regulator of G-protein signaling 19 interacting protein 1 , semaF cytoplasmic domain associated protein , semaF cytoplasmic domain-associated protein 1 , GLUT1 C-terminal-binding protein , GLUT1CBP , RGS-GAIP interacting protein C-terminus , RGS-GAIP interacting protein, C-terminus

822259 Arabidopsis thaliana
496793 Xenopus (Silurana) tropicalis
717785 Macaca mulatta
747668 Pan troglodytes
692815 Bombyx mori
5576629 Aedes aegypti
8355749 Schistosoma mansoni
519617 Bos taurus
445568 Danio rerio
398204 Xenopus laevis
10755 Homo sapiens
484902 Canis lupus familiaris
67903 Mus musculus
83823 Rattus norvegicus
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