Browse our Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 Proteins (SLC1A1)

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Synonyms:
D130048G10Rik, Eaac1, EAAC2, Eaat3, GB16911, MEAAC1, REAAC1, SCZD18, SLC1A2a, zgc:91959
list all proteins Gene Name GeneID UniProt
SLC1A1 6505 P43005
SLC1A1 20510 P51906
Rat SLC1A1 SLC1A1 25550 P51907

Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 Proteins (SLC1A1) by Origin

More Proteins for Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 Interaction Partners

Human Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1) interaction partners

  1. Numb (show NUMB Proteins) is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 through binding the YxNxxF (where x stands for any amino acid) motif.

  2. observations provide insights into the molecular basis of hot water epilepsy and show the role of SLC1A1 variants in this intriguing neurobehavioral disorder

  3. This study demonstrated that Variations within SLC1A1 are associated with risk of epileptogenesis following posttraumatic brain injury.

  4. Lithium-sensitive GSK3ss is a powerful regulator of excitatory amino acid transporters EAAT3 and EAAT4 (show SLC1A6 Proteins).

  5. Data suggest that EAAC1 transporters present on NST (show SULT4A1 Proteins) dendrites may play a minor role if any in glutamate (show GRIN1 Proteins) clearance.

  6. SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are negative regulators of EAAT3 activity

  7. Excitatory amino acid carrier 1 (EAAC1) plays a pivotal role in neuronal glutathione synthesis to maintain cellular redox homeostasis.

  8. Transport of either L-glutamate (show GRIN1 Proteins) or L-selenocysteine by EAAT3 decreased intracellular pH, whereas transport of cysteine resulted in cytoplasmic alkalinization.

  9. variability within the SLC1A1 gene impacts both the presence and severity of posttraumatic stress disorder among a sample of combat-exposed veterans.

  10. Our data suggest that SLC1A1 is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese

Mouse (Murine) Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1) interaction partners

  1. this paper shows increased EAAC1 protein expression in lysates from livers of NOD mice compared with B6 mice

  2. These findings suggest that cysteine uptake by EAAC1 is important for neuronal antioxidant function under ischemic conditions.

  3. these studies indicate that absence of EAAC1 results in either a decrease in pilocarpine-induced seizures that is not detectable by behavioral criteria

  4. EAAT3 is upstream of PKA in a pathway to regulate GluR1 (show GRIA1 Proteins) trafficking.

  5. EAAT3/EAAC1 expression is altered in murine models of human neurodegenerative diseases. (Review)

  6. These results suggest that the isoflurane preconditioning-induced acute phase of neuroprotection involves EAAT3.

  7. These findings indicate that regulation of heart rate, a vital sign, is one of the EAAT (show SLC1A2 Proteins) biological functions.

  8. Study implicates EAAC1-dependent cysteine uptake as an endogenous source of enhancing antioxidant function and zinc homeostasis in neurons in the ischemic brain.

  9. This study showed that these relatively small amounts of EAAC1 protein are widely distributed in somata and dendrites of all hippocampal neurons.

  10. These findings identify a mechanism whereby Nrf2 (show NFE2L2 Proteins) activation can coordinate astrocyte glutathione release with neuronal glutathione synthesis through transcriptional upregulation of neuronal EAAT3 expression.

Pig (Porcine) Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1) interaction partners

  1. Data suggest that expression of SLC1A1 in intestinal epithelial cells can be regulated by dietary components; expression of SLC1A1 is up-regulated by L-glutamate (show GRIN2C Proteins), an abundant dietary amino acid and dietary supplement.

  2. These findings indicate that the expression of the EAAC1 in jejunum is much depending on the stage of piglet development and that low BW at birth is associated with lower expression of this carrier in the early suckling period.

  3. Glutamate (show GRIN2C Proteins) uptake across apical membrane is regulated by changing expression of EAAC-1 at transcription and translation levels as well as maximal uptake activity and transporter affinity along the intestinal crypt-villus axis in the neonate.

Rabbit Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1) interaction partners

  1. This study is focused on the assessment of non-exocytotic glutamate (show GRIN2A Proteins) release, that is, the unstimulated release, heteroexchange and glutamate transporter reversal in platelets.

Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1) Protein Profile

Protein Summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.

Alternative names and synonyms associated with Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1)

  • excitatory amino acid transporter 3 (Eaat-3)
  • solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (slc1a1)
  • excitatory amino acid transporter 3 (EAAT3)
  • excitatory amino acid transporter 3 (CpipJ_CPIJ000674)
  • excitatory amino acid transporter 3 (CpipJ_CPIJ001134)
  • solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (SLC1A1)
  • solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (Slc1a1)
  • D130048G10Rik protein
  • Eaac1 protein
  • EAAC2 protein
  • Eaat3 protein
  • GB16911 protein
  • MEAAC1 protein
  • REAAC1 protein
  • SCZD18 protein
  • SLC1A2a protein
  • zgc:91959 protein

Protein level used designations for SLC1A1

excitatory amino acid transporter 3 , excitatory amino acid carrier 1 , neuronal and epithelial glutamate transporter , sodium-dependent glutamate/aspartate transporter 3 , solute carrier family 1 member 1 , excitatory amino acid carrier 2 , excitatory amino-acid carrier 1 , glutamate transporter mEAAC2 , solute carrier family 1, member 1 , Solute carrier family 1 A1 (brain glutamate transporter) , excitatory amino acid transporter-3 , glutamate transporter , renal high affinity glutamate transporter EAAC1 , high-affinity glutamate transporter

GENE ID SPECIES
412382 Apis mellifera
436939 Danio rerio
443514 Ovis aries
6031434 Culex quinquefasciatus
6032150 Culex quinquefasciatus
6505 Homo sapiens
20510 Mus musculus
25550 Rattus norvegicus
403751 Canis lupus familiaris
397003 Sus scrofa
282353 Bos taurus
100009070 Oryctolagus cuniculus
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