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this study shows that IL-2 (show IL2 ELISA Kits)-induced expression of SLC1A5 is a prerequisite for NKG2D (show KLRK1 ELISA Kits)-mediated activation of NK cells
we found that PPARdelta (show PPARD ELISA Kits) directly regulated neutral amino acid transporter (show SLC6A19 ELISA Kits) SLC1 (show MCHR1 ELISA Kits)-A5 (solute carrier family 1 member 5) and glucose transporter-1 (Glut1 (show SLC2A1 ELISA Kits)) gene transcription, leading to uptake of glucose and amino acid, activation of mTOR (show FRAP1 ELISA Kits) signaling, and tumor progression. In contrast, silence of PPARdelta (show PPARD ELISA Kits) or its antagonist inhibited this event.
Data suggest that both heterogeneous nuclear ribonucleoprotein (show PCBP2 ELISA Kits) type M (HNRPM (show HNRNPM ELISA Kits)) and solute carrier 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer.
Both stable and inducible shRNA-mediated ASCT2 knockdown confirmed that inhibiting ASCT2 function was sufficient to prevent cellular proliferation and induce rapid cell death in TN basal-like breast cancer cells, but not in luminal cells.
ASCT2 is an EGFR (show EGFR ELISA Kits)-associated protein that can be co-targeted by cetuximab, leading to sensitization of cetuximab-treated cells to ROS (show ROS1 ELISA Kits)-induced apoptosis.
The tumor metabolism status determined by expression of GLUT1 (show SLC2A1 ELISA Kits) and ASCT2.
Data show that SERT (show SLC6A4 ELISA Kits) associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT (show SLC6A4 ELISA Kits) in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.
High expression of LAT1 (show LAT ELISA Kits) and ASCT2 correlates with metastasis and invasion in esophageal squamous cell carcinoma.
LAT1 (show LAT ELISA Kits), 4F2hc (show SLC3A2 ELISA Kits) and ASCT2 were highly expressed in patients with advanced laryngeal cancer.
These findings highlight a mechanism of T cell activation involving ASCT2-dependent integration of the T cell receptor signal and a metabolic signaling pathway.
used as receptor by HERV-W Env glycoproteins when their sites for N-linked glycosylation are eliminated by mutagenesis
results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 (show SLC1A4 ELISA Kits) and ASCT2 receptors
amino acid transporter B(0)/ASC transporter 2 expression is necessary for SK-Hep cell growth
ASCT1 (show SLC1A4 ELISA Kits) and ASCT2 mRNA were expressed in cultured blood-brain barrier[BBB (show ALMS1 ELISA Kits)] cells; expression of ASCT2 mRNA was 6.7-fold greater. ASCT2 is localized at the abluminal side of the mouse BBB (show ALMS1 ELISA Kits), suggesting a key role in l-isomer-selective Asp (show C3 ELISA Kits) transport at the BBB (show ALMS1 ELISA Kits)
data support ASCT2 function in both neuron and astrocyte cultures and identify a discrepancy between observed asc-1 (show SLC7A10 ELISA Kits) immunoreactivity and lack of functional asc-1 (show SLC7A10 ELISA Kits) activity in neuron cultures, elucidating processes that govern D-serine regulation
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001
neutral amino acid transporter B(0)
, RD114 virus receptor
, RD114/simian type D retrovirus receptor
, baboon M7 virus receptor
, neutral amino acid transporter B
, sodium-dependent neutral amino acid transporter type 2
, solute carrier family 1 member 5
, alanine/serine/cysteine/threonine transporter 2
, neutral amino acid transporter B0
, ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
, insulin-activated amino acid transporter
, solute carrier family 1, member 7
, CAZ-associated structural protein
, H4-system ASC-like transporter
, sodium-dependent neutral amino acid transporter ASCT2