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disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion
Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 (show SSX2 Proteins) tumors. Re-analysis of human SS18-SSX1 (show SSX1 Proteins) and SS18-SSX2 (show SSX2 Proteins) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (show SSX2 Proteins) expression in SS18-SSX1 (show SSX1 Proteins) tumors.
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 (show BICD1 Proteins) and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.
Data show that SS18/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 (show AXIN2 Proteins) in primary synovial sarcoma.
a rare variant of the SS18-SSX1 (show SSX1 Proteins) fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed
Case Report: bronchial biphasic synovial sarcoma with SS18 gene rearrangement.
SS18-SSX (show SSX2 Proteins)-induced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.
SYT gene split is associated with Synovial sarcoma.
These results suggest that the characteristic speckle localization pattern of SS18-SSX (show SSX2 Proteins) is strongly involved in the tumorigenesis through the SSX (show SSX2 Proteins) moiety of the SS18-SSX (show SSX2 Proteins) fusion protein.
Knockdown of SS18-SSX1 (show SSX1 Proteins) in synovial sarcoma inhibits viability and induces apoptosis.
SS18-SSX (show SSX2 Proteins) fusion type is a significant prognostic factor for patients with synovial sarcoma.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, synovial sarcoma associated SS18-beta
, synovial sarcoma associated SS18-delta
, synovial sarcoma associated SS18-gamma
, synovial sarcoma, translocated to X chromosome
, synovial sarcoma-associated Ss18-alpha
, synovial sarcoma translocated to X chromosome protein
, synovial sarcoma translocation, chromosome 18
, synovial sarcoma translocation, chromosome 18 L homeolog