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This study found that the CSF (show CSF2 Proteins) levels of synaptotagmin-1 (show SYT1 Proteins) were consistently elevated in patients with dementia due to Alzheimer's disease.
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 (show SSX2 Proteins) tumors. Re-analysis of human SS18-SSX1 (show SSX1 Proteins) and SS18-SSX2 (show SSX2 Proteins) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (show SSX2 Proteins) expression in SS18-SSX1 (show SSX1 Proteins) tumors.
SYT-SSX (show SSX2 Proteins) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (show CA2 Proteins)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (show CA2 Proteins)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (show SYT1 Proteins) and Syt-7 (show SYT7 Proteins) isoforms.
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 (show BICD1 Proteins) and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.
Data show that SS18/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 (show AXIN2 Proteins) in primary synovial sarcoma.
These findings identify Syt1 (show SYT1 Proteins) as a novel Ca(2 (show CA2 Proteins)+)-sensitive PS1 (show PSEN1 Proteins) modulator that could regulate synaptic ABETA (show APP Proteins), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT-SSX (show SSX2 Proteins) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (show CA2 Proteins)+).
disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion
Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, protein SSXT
, synovial sarcoma translocated to X chromosome protein
, synovial sarcoma, translocated to X chromosome
, synovial sarcoma associated SS18-beta
, synovial sarcoma associated SS18-delta
, synovial sarcoma associated SS18-gamma
, synovial sarcoma-associated Ss18-alpha