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Mouse (Murine) TRPV1 ELISA Kit for Sandwich ELISA - ABIN428807
Rehman, Bhat, Panda, Mabalirajan: TRPV1 inhibition attenuates IL-13 mediated asthma features in mice by reducing airway epithelial injury. in International immunopharmacology 2013
Results demonstrate that cell motility and Ca(2 (show CA2 ELISA Kits)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
The TRPV1 transcript was present in prostate cancer-affected foci, both in the tumor tissue as well as in the adjacent untransformed part of the gland. All breast carcinoma cell lines showed robust expression of TRPV1. Trigeminal ganglion expressed significantly higher levels of TRPV1 protein than either breast or prostate cancer cells. Ectopic expression of TRPV1 decreases cancer cell survival by induction of apoptosis.
This activity is independent of the NGF (show NGFB ELISA Kits) pathway and is not mediated by known TRPV1 toxins' binding sites.
It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX (show SLC24A6 ELISA Kits) and MCU (show MCU ELISA Kits).
Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca(2 (show CA2 ELISA Kits)+) oscillations.
The distinct localization of TRPV1 receptor, supports the concept of a role in the functional activity of the trigeminal sensory system.
The slow sustained current mediated by TRPV1.
This study suggests that the TRPV1 channel is involved in interferon beta (show IFNB1 ELISA Kits)-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis.
Respiratory syncytial virus and measles virus infection upregulates TRPV1 expression in bronchial epithelial cells.
These studies suggest that TRPV1 is expressed on airway smooth muscle.
These findings indicate the EPO (show EPO ELISA Kits)-induced Ca(2 (show CA2 ELISA Kits)+) influx via the activation of the PLC-gamma1 (show PLCG1 ELISA Kits) signalling pathway, which leads to TRPV1 activation and consequently increases...angiogenesis.
The activation of TRPV1 channels by dietary capsaicin triggers browning of white adipose tissue to counteract obesity. The results suggest that activation of TRPV1 channels is a promising strategy to counter obesity.
study demonstrates that the anti-inflammatory effects of N-Arachidonoyl dopamine are mediated by TRPV1 expressed by nonhematopoietic cells and provide data suggesting that neuronal TRPV1 may mediate NADA's anti-inflammatory effects
These findings demonstrate functional expression and the precise ultrastructural localization of TRPA1 (show TRPA1 ELISA Kits) and TRPV1 ion channels in freshly isolated mouse CMs (show Cd2ap ELISA Kits). Crosstalk between TRPA1 (show TRPA1 ELISA Kits) and TRPV1 may be important in mediating cellular signaling events in cardiac muscle
TRPA1 (show TRPA1 ELISA Kits) and TRPV1 appear to contribute to the propofol-mediated antagonism of U46619-induced constriction in murine coronary microvessels that involves activation of NOS (show NOS ELISA Kits) and BKCa (show KCNMA1 ELISA Kits).
Study showed that activation of TRPV1 and blockade of NMDA receptors produced antidepressant-like effects in male mice following amphetamine withdrawal, and these receptors are involved in amphetamine withdrawal-induced depressive-like behaviors; rapid antidepressant-like effects of capsaicin in forced swimming test and splash (show PLA2G2D ELISA Kits) test are partly mediated by NMDA receptors
TRPV1 channel is essential for innocuous warmth detection, but not for noxious heat detection.
These data show that predominantly in postpubertal female mice, bladder arterial smooth muscle cells express functional TRPV1 channels that may act to constrict arterioles. TRPV1 may therefore play an important role in regulating the microcirculation of the female bladder
Results indicate that vanillin, a selective agonist of TRPV1 and donepezil, a potent acetylcholine esterase (show AChE ELISA Kits) inhibitor have attenuated intracerebroventricular streptozotocin and AlCl3+d-galactose induced experimental Alzheimer's disease. Hence, pharmacological positive modulation of TRPV1 channels may be a potential research target for mitigation of Alzheimer's disease.
TrpV1 KO mice displayed less total activity than WT only when submitted to LD. We provide evidence that TRPV1 is an important modulator of BAT (show BAAT ELISA Kits) clock gene oscillations
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (show CA2 ELISA Kits)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (show TBXA2R ELISA Kits) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (show CALCA ELISA Kits) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (show AQP5 ELISA Kits) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein