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These data suggest functional requirements for Ku and XRCC4 (show XRCC4 Proteins) in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF.
APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation.
Polynucleotide kinase and aprataxin-like (show APTX Proteins) forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease (show EXO1 Proteins) and can participate in DNA end joining in a biochemical system.
only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (show XRCC1 Proteins) (Arg280His
APLF has a role in chromosomal DNA double-strand break repair.
The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone.
The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger.
These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells.
PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
APLF is an ATM (show ATM Proteins) target that is involved in nonhomologous end-joining and facilitates double-strand break repair, likely via interactions with Ku and XRCC4 (show XRCC4 Proteins)-DNA ligase IV (show LIG4 Proteins).
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007
aprataxin and PNKP like factor
, aprataxin and PNK-like factor-like
, PNK and APTX-like FHA domain-containing protein
, PNK and APTX-like FHA protein
, XRCC1-interacting protein 1
, aprataxin and PNK-like factor
, aprataxin- and PNK-like factor
, apurinic-apyrimidinic endonuclease APLF