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Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR.
Abraxas and RAP80 (show UIMC1 Proteins) were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair.
CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.
CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
the human Ubc13 (show UBE2N Proteins)/Rnf8 (show RNF8 Proteins) ubiquitin ligases control foci formation of the Rap80 (show UIMC1 Proteins)/Abraxas/Brca1/Brcc36 (show BRCC3 Proteins) complex in response to DNA damage
Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2 (show BRCA2 Proteins), suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene.
it seems unlikely that moderate to highly penetrant alleles of either RAP80 (show UIMC1 Proteins) or Abraxas, confer a significantly high relative risk of breast cancer.
examined RAP80 (show UIMC1 Proteins) and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of brca1 (By similarity).
coiled-coil domain containing 98
, BRCA1-A complex subunit Abraxas
, Protein FAM175A
, abraxas protein
, coiled-coil domain-containing protein 98