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Collectively, this study illustrates the interplay between ALDH(high) CSCLs and EOC invasion, and offers a novel application target for the EOC oncotherapy.
Findigs suggest that aldehyde dehydrogenase 1 (ALDH1) played an important role in tumor aggressiveness and associated with a tumor-promoting microenvironment in esophageal cancer.
These results suggested that tumor-secreting factor increases ALDH(high) TEC populations that are resistant to 5-FU. Therefore, ALDH(high) TEC in tumor blood vessels might be an important target to overcome or prevent drug resistance.
Results demonstrate that EZH2 (show EZH2 Proteins) and ALDH1 proteins are expressed in the stromal component of phyllodes tumors.
High ALDH1A1 expression is associated with cervical cancer.
Study shows that BPA (show DST Proteins) induces ALDH1 expression in MCF-7 Cells and increases mammosphere size.
High ALDH expression is associated with Prostate Cancer.
High ALDH1 expression is associated with endometrial cancer.
A central role of Aurora kinase A (AURKA (show AURKA Proteins)) in promoting Epithelial-to-mesenchymal transition and cancer stem cell phenotypes via ALDH1A1.
ALDH1A1 modulates the production of ROS (show ROS1 Proteins) by anti-cancer agents such as paclitaxel and diminishes their efficacy.
analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2 (show ALDH2 Proteins)
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO (show NONO Proteins))/paraspeckle protein component 1 (PSPC1 (show PSPC1 Proteins))-aldehyde dehydrogenase 1 (NONO (show NONO Proteins)/PSPC1 (show PSPC1 Proteins)-ALDH1A1) in the modulation of Sertoli cells (SCs (show TWIST1 Proteins)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
these experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).
Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A.
Dkk-1 (show DKK1 Proteins) enhances resistance of osteosarcoma cells to stress by tipping balance of Wnt (show WNT2 Proteins) signaling in favor of the non-canonical Jun (show JUN Proteins)-mediated Wnt (show WNT2 Proteins) pathways. In turn, this results in transcriptional activation of ALDH1 through Jun (show JUN Proteins)-responsive promoter elements.
Deletion of Aldh1a1 exacerbated alpha-synuclein-mediated DA neurodegeneration and alpha-synuclein aggregation, whereas Aldh1a1-null and control DA neurons were comparably susceptible to 1-methyl-4-phenylpyridinium-, glutamate (show GRIN1 Proteins)-, or camptothecin-induced cell death.
Our findings indicated that increased expression of ALDH1A1 in nasopharyngeal carcinoma was associated with enhanced invasiveness in the nude mouse.
PSMB8 (show PSMB8 Proteins), ALDH1A1, and HSPA4 (show HSPA4 Proteins) were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
beta-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA (show RHOA Proteins)/Rock signaling
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
aldehyde dehydrogenase 1A1
, retinal dehydrogenase 1
, aldehyde dehydrogenase 1 family, member A1
, aldehyde dehydrogenase class 1
, retinal dehydrogenase 1-like
, aldehyde dehydrogenase
, aldehyde dehydrogenase family protein
, NADP-dependent fatty aldehyde dehydrogenase
, ALDH class 1
, RALDH 1
, acetaldehyde dehydrogenase 1
, aldehyde dehydrogenase 1, soluble
, aldehyde dehydrogenase, liver cytosolic
, retinaldehyde dehydrogenase 1
, chromosome 1 GSS clone AHT1-34
, aldehyde dehydrogenase 1, subfamily A1
, aldehyde dehydrogenase 2
, aldehyde dehydrogenase family 1 member A1
, aldehyde dehydrogenase family 1, member A1
, aldehyde dehydrogenase family 1, subfamily A1
, aldehyde dehydrogenase, cytosolic
, cytosolic aldehyde dehydrogenase
, ALDH class 2
, aldehyde dehydrogenase 2, mitochondrial
, aldehyde dehydrogenase, mitochondrial
, mitochondrial aldehyde dehydrogenase
, alcohol dehydrogenase family 1, subfamily A1
, alcohol dehydrogenase family 1, subfamily A2
, aldehyde dehydrogenase 1, liver cytosolic (class 1)