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Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2 (show CA2 Proteins)+) signaling, was the major host cell PilA binding protein.
A novel interaction between calcium-modulating cyclophilin ligand and Basigin (show BSG Proteins) regulates calcium signaling and matrix metalloproteinase (show MMP20 Proteins) activities in human melanoma cells.
Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB (show WRB Proteins) as components of the TRC40 (show ASNA1 Proteins) receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
CAML was found to play a crucial role in the PRL (show PRL Proteins)/PRLR (show PRLR Proteins)-dependent growth of breast cancer cells.
this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production.
Data show that tetherin (show BST2 Proteins) restricts particle release and does not require CAML for this effect.
CAMLG was more frequently significantly overexpressed in acute myeloid leukemia (show BCL11A Proteins) patients with CD56 (show NCAM1 Proteins) immunophenoytpe
Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2 (show CA2 Proteins)+) response, which consequently protects cells from mitochondrial damage and apoptosis
CAML is an important signal transducer for the actions of Ang II (show AGT Proteins) in regulating the calcineurin (show PPP3CA Proteins)-NFAT (show NFATC1 Proteins) pathway and the interaction of CAML with ATRAP (show AGTRAP Proteins) may mediate the Ang II (show AGT Proteins) actions in vascular physiology
The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2 (show PKD2 Proteins).
Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Conditional deletion of CAML in CD19 (show CD19 Proteins)-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Loss of CAMLG protein failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis.
results implicate Tmub1 (show TMUB1 Proteins) in the regulation of locomotor activity and wakefulness and suggest that Tmub1 (show TMUB1 Proteins) binds to and functions together with CAMLG
These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor (EGF (show EGF Proteins)) receptor (show EGFR Proteins) signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF (show EGF Proteins).
CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase (show LCK Proteins) p56 (show IFIT1 Proteins)(p56Lck (show LCK Proteins)) signaling.
specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A) receptors
our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC (show ADCY10 Proteins) maintenance.
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
calcium modulating ligand
, calcium signal-modulating cyclophilin ligand
, calcium modulating cyclophilin ligand CAML
, calcium-modulating cyclophilin ligand
, calcium-signal modulating cyclophilin ligand
, cyclophilin B-binding protein