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only the SH3 domains of CD2AP (show Cd2ap ELISA Kits) are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51 (show RET ELISA Kits)
Accumulation of c-Cbl (show CBL ELISA Kits) and rapid termination of colony-stimulating factor 1 receptor (show CSF1R ELISA Kits) signaling in interferon consensus sequence binding protein (show IRF8 ELISA Kits)-deficient bone marrow-derived macrophages
Results describe the detailed expression pattern of murine Cbl-3 and report the generation and characterization of Cbl-3-deficient mice.
c-Cbl (show CBL ELISA Kits) deficiency did not affect Fc epsilon RI-induced histamine release or total cellular protein phosphorylation. Its absence increased ERK (show EPHB2 ELISA Kits) phosphorylation after receptor stimulation, but resulted in reduced p38 (show CRK ELISA Kits) phosphorylation & Ca(2 (show CA2 ELISA Kits)+) response.
MMTV-CBLC transgenic mice show abnormal mammary gland development
Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus.
Silencing of CBLC causes increased sensitivity to PARP1 (show PARP1 ELISA Kits) inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause.
the effects of two pathogenic missense mutations on the the catalytic activities of the human B12 (show NDUFB3 ELISA Kits)-processing chaperone CblC
This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients
The ubiquitin ligase activity of Cbl (show CBL ELISA Kits)-c by the direct interaction of the LIM (show PDLIM5 ELISA Kits) zinc coordinating domain of Hic5 (show TGFB1I1 ELISA Kits) is demonstrated.
the N terminus of Cbl (show CBL ELISA Kits)-c contributes to the binding to the E2 and phosphorylation of Tyr (show TYR ELISA Kits)-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl (show CBL ELISA Kits)-c
Data demonstrate that two E3 ligases of different classes, CBLC and AIP4 (show ITCH ELISA Kits), can interact and cooperate to down-regulate EGFR (show EGFR ELISA Kits) signaling.
c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis.
Src (show SRC ELISA Kits) is a preferential target of Cbl (show CBL ELISA Kits)-c for degradation
ubiquitin protein ligase (show UBE2K ELISA Kits) activity is regulated in c-Cbl (show CBL ELISA Kits) by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate (show GRIN1 ELISA Kits) point mutations
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
, Casitas B-lineage lymphoma c
, Cbl proto-oncogene, E3 ubiquitin protein ligase C
, SH3-binding protein CBL-3
, SH3-binding protein CBL-C
, signal transduction protein CBL-C
, Cas-Br-M (murine) ectropic retroviral transforming sequence c
, RING finger protein 57