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Loss of SNX-1 (show SNX1 Proteins), RME-8, or the clathrin chaperone Hsc70 (show HSPA8 Proteins)/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 (show RAE1 Proteins) to the lysosome.
The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 (show CAV1 Proteins) fused to GFP is reported.
Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization
Data indicate that clathrin-mediated endocytosis of proto-oncogene (show RAB1A Proteins) protein erbB-3 (ErbB3 (show ERBB3 Proteins)) is depending on epsin-1 (show EPN1 Proteins).
Upon receptor activation, prostate alpha1A-adrenoceptors bind clathrin LCA.
IGF1R (show IGF1R Proteins) internalization and co-localization with clathrin and CAV1 (show CAV1 Proteins) upon ligand binding, as well as the status of the IGF1R (show IGF1R Proteins) pathway, cellular proliferation, and the apoptosis of interfered and inhibited Ewing's sarcoma, were analyzed.
upon ligand activation, CysLT(1 (show CYSLTR1 Proteins))R is tyrosine-phosphorylated and released from heterodimers with CysLT(2 (show CYSLTR2 Proteins))R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3 (show ARRB2 Proteins)-, and Rab-5 (show RAB5A Proteins)-dependent manner
Data show that MAD2B (show MAD2L2 Proteins) interacts with CLTA during the G2/M phase of the cell cycle and that depletion of MAD2B (show MAD2L2 Proteins) leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis.
Human Rhinovirus 2 uses clathrin-mediated endocytosis to infect cells
Data suggest that clathrin heavy chains bound to light chains (LC) a and b contribute to pit formation, but the affinity of LCa-free HC in pits is reduced, and the Ca(2+)- and ATP-mediated control of clathrin function is lost.
in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures
Structure of clathrin coat with bound Hsc70 (show HSPA8 Proteins) and auxilin (show DNAJC6 Proteins).
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.
Clathrin LIght Chain family member (clic-1)
, clathrin, light chain (Lca)
, clathrin, light polypeptide A
, light chain (Lca)
, clathrin light chain A
, clathrin, light polypeptide (Lca)
, clathrin light chain
, Clathrin light chain
, clathrin, light chain A2
, clathryn light chain (LCA2)