Complexin 1 antibody (AA 31-100)
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- Target See all Complexin 1 (CPLX1) Antibodies
- Complexin 1 (CPLX1)
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Binding Specificity
- AA 31-100
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Reactivity
- Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Complexin 1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Mouse, Rat
- Predicted Reactivity
- Human,Cow,Pig,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human CPLX1
- Isotype
- IgG
- Top Product
- Discover our top product CPLX1 Primary Antibody
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anti-Complexin 1 (CPLX1) (AA 1-134) antibody
CPLX1 Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-Complexin 1 (CPLX1) (N-Term) antibodyCPLX1 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Complexin 1 (CPLX1) (AA 1-134) antibodyCPLX1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Complexin 1 (CPLX1) (AA 33-60) antibodyCPLX1 Reactivity: Mouse WB, IHC (p) Host: Rabbit Polyclonal RB23961 unconjugated
anti-Complexin 1 (CPLX1) (AA 1-134) antibody (PE)CPLX1 Reactivity: Human IHC, ICC, IF, FACS Host: Rabbit Polyclonal PE
anti-Complexin 1 (CPLX1) (AA 1-134) antibody (APC)CPLX1 Reactivity: Human IHC, ICC, IF, FACS Host: Rabbit Polyclonal APC
anti-Complexin 1 (CPLX1) (AA 39-69), (Middle Region) antibodyCPLX1 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- Complexin 1 (CPLX1)
- Alternative Name
- CPLX1 (CPLX1 Products)
- Synonyms
- MGC84299 antibody, CPLX1 antibody, CPX-I antibody, CPX1 antibody, 921-S antibody, complexin 1 L homeolog antibody, complexin 1 antibody, cplx1.L antibody, CPLX1 antibody, cplx1 antibody, Cplx1 antibody
- Background
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Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.
Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.
- Pathways
- Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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