DLAT antibody
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- Target See all DLAT Antibodies
- DLAT (Dihydrolipoyl Transacetylase (DLAT))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DLAT antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human DLAT (NP_001922.2).
- Isotype
- IgG
- Top Product
- Discover our top product DLAT Primary Antibody
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anti-Dihydrolipoyl Transacetylase (DLAT) (AA 368-626) antibody
DLAT Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 87-270) antibodyDLAT Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 579-607), (C-Term) antibodyDLAT Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB26843 unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 1-647) antibodyDLAT Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 1-647) antibodyDLAT Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (N-Term) antibodyDLAT Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (N-Term) antibodyDLAT Reactivity: Human, Mouse, Rat, Rabbit, Dog, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 26-217) antibodyDLAT Reactivity: Human WB, ELISA, IP Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) antibodyDLAT Reactivity: Human, Mouse, Rat IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 61-110) antibodyDLAT Reactivity: Human, Mouse, Rat, Rabbit, Dog, Zebrafish (Danio rerio), Cow, Pig, Guinea Pig, Horse, Monkey, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- DLAT (Dihydrolipoyl Transacetylase (DLAT))
- Alternative Name
- DLAT (DLAT Products)
- Synonyms
- DLAT antibody, Dmel\\CG5261 antibody, EP(2)0816 antibody, EP816 antibody, anon-WO0118547.121 antibody, DLTA antibody, PDC-E2 antibody, PDCE2 antibody, wu:fc14f10 antibody, wu:fc21f08 antibody, wu:fc86g11 antibody, wu:fj57d06 antibody, 6332404G05Rik antibody, midline uncoordinated antibody, dihydrolipoamide S-acetyltransferase L homeolog antibody, dihydrolipoamide S-acetyltransferase antibody, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) antibody, muc antibody, dlat.L antibody, DLAT antibody, Dlat antibody, dlat antibody
- Background
- This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
- Molecular Weight
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Observed_MW: 69 kDa
Calculated_MW: 68 kDa
- Gene ID
- 1737
- UniProt
- P10515
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