Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 101-200) antibody
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- Target See all Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antibodies
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
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Binding Specificity
- AA 101-200
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human RNF56/CBL-B
- Isotype
- IgG
- Top Product
- Discover our top product CBLB Primary Antibody
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anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 103-130) antibody
CBLB Reactivity: Rat WB, IHC (p), FACS Host: Rabbit Polyclonal RB21574 unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (N-Term) antibodyCBLB Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-350) antibodyCBLB Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) antibodyCBLB Reactivity: Human WB, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 862-889), (C-Term) antibodyCBLB Reactivity: Mouse WB Host: Rabbit Polyclonal RB39998 unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (C-Term) antibodyCBLB Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
- Alternative Name
- Rnf56 (CBLB Products)
- Synonyms
- rnf56 antibody, cblb antibody, AI429560 antibody, AI851073 antibody, Cbl-b antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antibody, Casitas B-lineage lymphoma b antibody, Cbl proto-oncogene B antibody, cblb.S antibody, cblb.L antibody, Cblb antibody, CBLB antibody
- Background
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Synonyms: Cbl-b, RNF56, Nbla00127, E3 ubiquitin-protein ligase CBL-B, Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B, CBLB
Background: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
- Gene ID
- 868
- UniProt
- Q13191
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