CBLC antibody (AA 245-474)
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- Target See all CBLC Antibodies
- CBLC (Cbl proto-oncogene C (CBLC))
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Binding Specificity
- AA 245-474
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CBLC antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
- Isotype
- IgG
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anti-Cbl proto-oncogene C (CBLC) (AA 444-458) antibody
CBLC Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibodyCBLC Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 424-453), (C-Term) antibodyCBLC Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0696 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-30), (N-Term) antibodyCBLC Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0694 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3F10 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC Reactivity: Human WB, FACS Host: Mouse Monoclonal 3B4 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC Reactivity: Human WB Host: Mouse Monoclonal 3D9 unconjugated
anti-Cbl proto-oncogene C (CBLC) antibodyCBLC Reactivity: Human WB, IF, IC Host: Rabbit Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (N-Term) antibodyCBLC Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CBLC (Cbl proto-oncogene C (CBLC))
- Alternative Name
- CBLC (CBLC Products)
- Synonyms
- CBL-3 antibody, CBL-SL antibody, RNF57 antibody, Cbl proto-oncogene C antibody, CBLC antibody, Cblc antibody
- Background
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Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at \\\'Tyr-419\\\'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.
Aliases: CBLC antibody, CBL3 antibody, RNF57E3 ubiquitin-protein ligase CBL-C antibody, EC 2.3.2.27 antibody, RING finger protein 57 antibody, RING-type E3 ubiquitin transferase CBL-C antibody, SH3-binding protein CBL-3 antibody, SH3-binding protein CBL-C antibody, Signal transduction protein CBL-C antibody
- UniProt
- Q9ULV8
- Pathways
- EGFR Signaling Pathway
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