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ATG7 antibody (N-Term)

Name: ATG7 antibody (N-Term)
SKU: ABIN6260108
Price: 390.77 USD
Availability: InStock

ATG7 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated

Western blot analysis of 293T lysate using ATG7 antibody. (ATG7 antibody (N-Term))

ABIN6276400 at 1/100 staining Human lymph node tissue by IHC-P. (ATG7 antibody (N-Term))

IHC

2 images

(1 reference)

Catalog No. ABIN6260108

Datasheet as PDF

Target See all ATG7 Antibodies

ATG7 (ATG7 Autophagy Related 7 (ATG7))
Binding Specificity
17

15

15

9

6

6

6

6

5

4

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
Reactivity
120

39

27

2

1

1

1

1

1

1

1
Human, Mouse, Rat
Host
108

13

2
Rabbit
Compatible Secondaries
Clonality
101

22
Polyclonal
Conjugate
62

9

8

7

6

5

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This ATG7 antibody is un-conjugated
Application
102

58

46

26

18

15

14

14

13

9

5

4

3

2

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity

ATG7 Antibody detects endogenous levels of total ATG7.

Predicted Reactivity

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human ATG7, corresponding to a region within N-terminal amino acids.

Isotype

IgG

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ATG7 Reactivity: Human WB, IHC, ELISA, ICC, FACS, Neut Host: Mouse Monoclonal 7D3E5 unconjugated

Application Notes

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date

12 months
Li, Li, Zeng, Yang, Liu, Zhang, Song, Yao, Ma, Li, Wang, Wei: "Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis." in: Journal of virology, Vol. 92, Issue 8, (2018) (PubMed).
Target

ATG7 (ATG7 Autophagy Related 7 (ATG7))

Alternative Name

ATG7 (ATG7 Products)

Synonyms

APG7-LIKE antibody, APG7L antibody, GSA7 antibody, D8 antibody, UBA1B antibody, UBE1L antibody, UBE2 antibody, Ube1l antibody, 1300004C08Rik antibody, AO090001000744 antibody, atg7 antibody, 1810013K23Rik antibody, Agp7 antibody, Apg7l antibody, Atg7l antibody, ATAPG7 antibody, ATATG7 antibody, ATG7 antibody, AUTOPHAGY 7 antibody, AUTOPHAGY-RELATED 7 antibody, K15I22.10 antibody, K15I22_10 antibody, autophagy related 7 antibody, ubiquitin like modifier activating enzyme 7 antibody, ubiquitin-like modifier activating enzyme 7 antibody, autophagy-related protein 7 antibody, Autophagy-related protein 7 antibody, Apg7p antibody, ThiF family protein antibody, ubiquitin-like conjugating enzyme Atg7 antibody, ATG7 antibody, UBA7 antibody, Uba7 antibody, ANI_1_3368024 antibody, AOR_1_1338164 antibody, PTRG_02236 antibody, PAAG_00287 antibody, PITG_12537 antibody, atg7 antibody, Atg7 antibody, APG7 antibody

Background

Description: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Gene: ATG7

Molecular Weight

78kDa

Gene ID

10533

UniProt

O95352

Pathways

Response to Water Deprivation, Autophagy