Sonic Hedgehog (SHH) Peptide
SHH
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all Sonic Hedgehog (SHH) products
- Sonic Hedgehog (SHH)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SHH antibody (Catalog #: ARP44235_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Sonic Hedgehog (SHH)
- Synonyms
- HHG1 Peptide, HLP3 Peptide, HPE3 Peptide, MCOPCB5 Peptide, SMMCI Peptide, TPT Peptide, TPTPS Peptide, 9530036O11Rik Peptide, Dsh Peptide, Hhg1 Peptide, Hx Peptide, Hxl3 Peptide, M100081 Peptide, fc83d08 Peptide, shh Peptide, syu Peptide, vhh-1 Peptide, vhh1 Peptide, wu:fc83d08 Peptide, Xhh Peptide, hedgehog Peptide, xshh Peptide, SHH Peptide, twh Peptide, twhh Peptide, sonic hedgehog Peptide, sonic hedgehog a Peptide, sonic hedgehog L homeolog Peptide, sonic hedgehog protein A Peptide, sonic hedgehog b Peptide, SHH Peptide, Shh Peptide, shha Peptide, shh.L Peptide, shh Peptide, shhb Peptide
- Background
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SHH is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in its gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.This gene, which is expressed only during embryogenesis, encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
Alias Symbols: HHG1, HLP3, HPE3, SMMCI, TPT, TPTPS, MCOPCB5
Protein Interaction Partner: ADCYAP1,GAS1,HHIP,PTCH1,PTCH2,SHH,SHH
Protein Size: 462 - Molecular Weight
- 28 kDa
- Gene ID
- 6469
- NCBI Accession
- NM_000193, NP_000184
- UniProt
- Q15465
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