ASIP antibody (AA 23-112)
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- Target See all ASIP Antibodies
- ASIP (Agouti Signaling Protein (ASIP))
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Binding Specificity
- AA 23-112
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ASIP antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Agouti-signaling protein (23-112AA)
- Isotype
- IgG
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anti-Agouti Signaling Protein (ASIP) (Internal Region) antibody
ASIP Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-Agouti Signaling Protein (ASIP) antibodyASIP Reactivity: Human IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ASIP (Agouti Signaling Protein (ASIP))
- Alternative Name
- ASIP (ASIP Products)
- Synonyms
- AGSW antibody, AGTI antibody, AGTIL antibody, ASP antibody, SHEP9 antibody, ASIP antibody, AA960621 antibody, AI256638 antibody, D8Ertd580e antibody, PAR-3 antibody, Par3 antibody, Pard3a antibody, agouti signaling protein antibody, par-3 family cell polarity regulator antibody, ASIP antibody, Asip antibody, asip antibody, Pard3 antibody
- Background
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Background: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Aliases: ASIP antibody, AGTI antibody, AGTIL antibody, ASP antibody, Agouti-signaling protein antibody, ASP antibody, Agouti switch protein antibody
- UniProt
- P42127
- Pathways
- Cell-Cell Junction Organization, Feeding Behaviour
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