RGMA antibody (AA 153-408)
-
- Target See all RGMA Antibodies
- RGMA (RGM Domain Family, Member A (RGMA))
-
Binding Specificity
- AA 153-408
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This RGMA antibody is un-conjugated
-
Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Repulsive guidance molecule A protein (153-408AA)
- Isotype
- IgG
-
anti-RGM Domain Family, Member A (RGMA) (AA 326-423) antibody
RGMA Reactivity: Human ELISA, WB Host: Mouse Monoclonal 6D7 unconjugated
anti-RGM Domain Family, Member A (RGMA) (AA 390-418), (C-Term) antibodyRGMA Reactivity: Human WB Host: Rabbit Polyclonal RB39658 unconjugated
anti-RGM Domain Family, Member A (RGMA) antibodyRGMA Reactivity: Human WB Host: Rabbit Monoclonal unconjugated
-
- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- RGMA (RGM Domain Family, Member A (RGMA))
- Alternative Name
- RGMA (RGMA Products)
- Synonyms
- RGM antibody, BC059072 antibody, C230063O06 antibody, repulsive guidance molecule family member a antibody, repulsive guidance molecule family member A antibody, RGMA antibody, Rgma antibody
- Background
-
Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody
- UniProt
- Q96B86
- Pathways
- Tube Formation
-
