CCDC47 antibody (AA 224-483)
CCDC47
Reactivity: Human
WB, IF
Host: Rabbit
Polyclonal
unconjugated
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- Target See all CCDC47 Antibodies
- CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))
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Binding Specificity
- AA 224-483
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CCDC47 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Purpose
- CCDC47 Rabbit pAb
- Sequence
- FLKRQDLLNV LARMMRPVSD QVQIKVTMND EDMDTYVFAV GTRKALVRLQ KEMQDLSEFC SDKPKSGAKY GLPDSLAILS EMGEVTDGMM DTKMVHFLTH YADKIESVHF SDQFSGPKIM QEEGQPLKLP DTKRTLLFTF NVPGSGNTYP KDMEALLPLM NMVIYSIDKA KKFRLNREGK QKADKNRARV EENFLKLTHV QRQEAAQSRR EEKKRAEKER IMNEEDPEKQ RRLEEAALRR EQKKLEKKQM KMKQIKVKAM
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).
- Isotype
- IgG
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anti-Coiled-Coil Domain Containing 47 (CCDC47) (AA 375-483) antibody
CCDC47 Reactivity: Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Coiled-Coil Domain Containing 47 (CCDC47) (C-Term) antibodyCCDC47 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))
- Alternative Name
- CCDC47 (CCDC47 Products)
- Synonyms
- MSTP041 antibody, 2610204L23Rik antibody, C88307 antibody, RP23-81G14.10 antibody, asp4 antibody, calumin antibody, RGD1308813 antibody, MGC80951 antibody, zgc:92099 antibody, coiled-coil domain containing 47 antibody, coiled-coil domain containing 47 S homeolog antibody, CCDC47 antibody, Ccdc47 antibody, ccdc47.S antibody, ccdc47 antibody
- Background
- Component of the PAT complex, an endoplasmic reticulum (ER-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs, releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity.,CCDC47,GK001,MSTP041,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,CCDC47
- Molecular Weight
- 55kDa
- Gene ID
- 57003
- UniProt
- Q96A33
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