Sos antibody
Reactivity: Human, Mouse, Non-Human Primate
WB, ICC
Host: Mouse
Monoclonal
SOS-01
unconjugated
-
- Target
- Sos
- Reactivity
- Human, Mouse, Non-Human Primate
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- Western Blotting (WB), Immunocytochemistry (ICC)
- Specificity
- The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.
- Cross-Reactivity (Details)
- Human, Mouse, Other not determined
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
- Clone
- SOS-01
- Isotype
- IgG1
-
-
- Application Notes
- Western blotting: Recommended dilution: 1 μg/mL, positive control: HeLa human cervix carcinoma cell line, reducing conditions.
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
-
- Target
- Sos
- Background
- SOS Ras/Rac guanine nucleotide exchange factor 1,The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.,SOS1, HGF, GGF1
- Gene ID
- 6654
- UniProt
- Q07889
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