TBCD antibody (AA 2-96)
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- Target See all TBCD Antibodies
- TBCD (Tubulin Folding Cofactor D (TBCD))
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Binding Specificity
- AA 2-96
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TBCD antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Tubulin-specific chaperone D protein (2-96AA)
- Isotype
- IgG
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anti-Tubulin Folding Cofactor D (TBCD) (AA 1-623) antibody
TBCD Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Tubulin Folding Cofactor D (TBCD) (AA 299-348) antibodyTBCD Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Tubulin Folding Cofactor D (TBCD) (N-Term) antibodyTBCD Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TBCD (Tubulin Folding Cofactor D (TBCD))
- Alternative Name
- TBCD (TBCD Products)
- Synonyms
- SSD-1 antibody, tfcD antibody, 2310057L06Rik antibody, A030005L14Rik antibody, mKIAA0988 antibody, tubulin folding cofactor D antibody, tubulin-specific chaperone d antibody, TBCD antibody, Tbcd antibody
- Background
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Background: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).
Aliases: Beta tubulin cofactor D antibody, Beta-tubulin cofactor D antibody, KIAA0988 antibody, SSD 1 antibody, SSD-1 antibody, SSD1 antibody, tbcd antibody, TBCD_HUMAN antibody, tfcD antibody, Tubulin folding cofactor D antibody, Tubulin specific chaperone D antibody, Tubulin-folding cofactor D antibody, Tubulin-specific chaperone D antibody
- UniProt
- Q9BTW9
- Pathways
- Cell-Cell Junction Organization
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