BRCC3 antibody (AA 14-316)
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- Target See all BRCC3 Antibodies
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
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Binding Specificity
- AA 14-316
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BRCC3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Lys-63-specific deubiquitinase BRCC36 protein (14-316AA)
- Isotype
- IgG
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anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibody
BRCC3 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 Reactivity: Human WB, ELISA, IHC, IHC (p) Host: Mouse Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316), (N-Term) antibodyBRCC3 Reactivity: Human WB, IHC (p), EIA Host: Mouse Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 36-70) antibodyBRCC3 Reactivity: Human WB Host: Rabbit Polyclonal RB54401 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 18-50) antibodyBRCC3 Reactivity: Human WB Host: Rabbit Polyclonal RB53911 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) antibody (FITC)BRCC3 Reactivity: Human WB, ELISA, IHC, IHC (p) Host: Rabbit Polyclonal FITC
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) antibodyBRCC3 Reactivity: Human WB, ELISA, IF, ICC Host: Mouse Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (C-Term) antibodyBRCC3 Reactivity: Human, Mouse, Rat, Horse, Pig, Monkey, Cow, Guinea Pig, Rabbit, Bat, Xenopus laevis WB Host: Rabbit Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (C-Term) antibodyBRCC3 Reactivity: Human, Rat, Horse, Pig, Monkey, Bat WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- Alternative Name
- BRCC3 (BRCC3 Products)
- Synonyms
- CXorf53 antibody, BRCC3 antibody, xtp1 antibody, brcc3 antibody, BRCC36 antibody, brcc36 antibody, C6.1A antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, DEP domain containing 1B antibody, BRCA1/BRCA2-containing complex, subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 3 L homeolog antibody, BRCC3 antibody, depdc1b antibody, brcc3 antibody, Brcc3 antibody, brcc3.L antibody
- Background
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Background: Metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains. Does not have activity toward \\\'Lys-48\\\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\'Lys-63\\\'-linked ubiquitin in various substrates. Mediates the specific \\\'Lys-63\\\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Aliases: BRCA1-A complex subunit BRCC36 antibody, BRCA1/BRCA2 containing complex subunit 3 antibody, BRCA1/BRCA2 containing complex subunit 36 antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 36 antibody, Brcc3 antibody, BRCC3_HUMAN antibody, BRCC36 antibody, BRISC complex subunit BRCC36 antibody, C6.1A antibody, Chromosome X open reading frame 53 antibody, CXorf53 antibody, Lys-63-specific deubiquitinase BRCC36 antibody, OTTHUMP00000061450 antibody
- UniProt
- P46736
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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