SPPL2A antibody (AA 26-172)
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- Target See all SPPL2A Antibodies
- SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
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Binding Specificity
- AA 26-172
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPPL2A antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
- Isotype
- IgG
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anti-Signal Peptide Peptidase-Like 2A (SPPL2A) (N-Term) antibody
SPPL2A Reactivity: Human ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Signal Peptide Peptidase-Like 2A (SPPL2A) (AA 108-138), (N-Term) antibodySPPL2A Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB2267 unconjugated
anti-Signal Peptide Peptidase-Like 2A (SPPL2A) (AA 31-129) antibodySPPL2A Reactivity: Human ELISA, WB Host: Mouse Monoclonal 1C7 unconjugated
anti-Signal Peptide Peptidase-Like 2A (SPPL2A) (AA 421-520) antibodySPPL2A Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Signal Peptide Peptidase-Like 2A (SPPL2A) (AA 31-129) antibodySPPL2A Reactivity: Human ELISA, WB Host: Mouse Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
- Alternative Name
- SPPL2A (SPPL2A Products)
- Synonyms
- RGD1563001 antibody, SPPL2A antibody, LOC453430 antibody, LOC100231183 antibody, IMP3 antibody, PSL2 antibody, 2010106G01Rik antibody, C130089K23Rik antibody, signal peptide peptidase-like 2A antibody, signal peptide peptidase like 2A antibody, Signal peptide peptidase-like 2A antibody, Sppl2a antibody, SPPL2A antibody, sppl2a antibody, psl2 antibody
- Background
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Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
Aliases: SPPL2A antibody, IMP3 antibody, PSL2 antibody, PSEC0147 antibody, Signal peptide peptidase-like 2A antibody, SPP-like 2A antibody, SPPL2a antibody, EC 3.4.23.- antibody, Intramembrane protease 3 antibody, IMP-3 antibody, Presenilin-like protein 2 antibody
- UniProt
- Q8TCT8
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