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Browse our anti-PTEN (PTEN) Antibodies

Full name:
anti-Phosphatase and Tensin Homolog Antibodies (PTEN)
On are 0 Phosphatase and Tensin Homolog (PTEN) Antibodies from different suppliers available. A total of 0 PTEN products are currently listed.
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
list all antibodies Gene Name GeneID UniProt
Anti-Mouse PTEN PTEN 19211 O08586
Anti-Rat PTEN PTEN 50557  
Anti-Human PTEN PTEN 5728 P60484

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More Antibodies against PTEN Interaction Partners

Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. In summary, our study illustrates the potential signal transduction process of PTEN while stimulated by LPS (show TLR4 Antibodies): by increasing the association of TLR4 (show TLR4 Antibodies), PTEN recruits to its phosphoinositide substrate PI(3,4,5)P3 located on the cell membrane and exerts its dephosphorylated function and subsequently depresses the activity of downstream molecule Akt (show AKT1 Antibodies) and results in activation of NF-kappaB (show NFKB1 Antibodies), followed by the secretion of inflamma...

  2. PTEN is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (show PDPK1 Antibodies) is required for stabilization of apical junctions during epithelial morphogenesis.

  3. Deletion of PTEN leads to phosphorylation of Serine 133 of Cyclic AMP Response Element-Binding protein, then increases the expression of microRNA-132.

  4. MiR-17-92 functions as a hepatocyte proliferation stimulator and acts in an estrogen-dependent manner. The loss of this miRNA results in increases in p21 (show D4S234E Antibodies) and Pten expression and therefore impairs liver regeneration in female mice.

  5. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Antibodies) signalling is significantly reduced in Pten() versus PIK3CA (show PIK3CA Antibodies)(H1047R) tumors. Thus, Pten() and PIK3CA (show PIK3CA Antibodies)(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  6. These results suggest that the social and anxiety-like phenotypes observed in CNS-specific Pten(-/-) mice may depend on neuronal Pten, as lack of Pten in Fsp1 (show S100A4 Antibodies)-expressing cells of the CNS had little effect on these behaviors.

  7. These findings demonstrate that melatonin attenuates cisplatin-induced follicle loss by preventing the phosphorylation of PTEN/AKT (show AKT1 Antibodies)/FOXO3a (show FOXO3 Antibodies) pathway members; thus, melatonin is a potential therapeutic agent for ovarian protection and fertility preservation during chemotherapy in female cancer patients.

  8. Identify miR (show MLXIP Antibodies)-382 as a promoter for hepatocyte proliferation and cell growth via targeting PTEN-Akt (show AKT1 Antibodies) axis

  9. Data suggest that PTEN phosphatase (PTEN) regulates renal extracellular matrix production via activated protein kinase B (Akt (show AKT1 Antibodies)) and increased connective tissue growth factor (CTGF (show CTGF Antibodies)) in diabetes mellitus.

  10. Methylseleninic acid superactivates p53 (show TP53 Antibodies)-senescence cancer progression barrier in prostate lesions of Pten-knockout mouse

Human Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. these findings were reversed with the LC3I/II-shPTEN treatment. Therefore, the loss of PTEN may promote the development of primary resistance to trastuzumab in breast cancer via autophagy defects

  2. PTEN promoter methylation is a mechanism partially responsible for PTEN silencing in sporadic breast cancer for North Indian women.

  3. This study indicated that patients with PTEN deletion were associated with higher pathological stage or Gleason score and a higher risk in prostate cancer.

  4. Among oral squamous cell carcinoma in south Indian subjects, the PTEN gene was methylated in 24%. PTEN and p16 (show CDKN2A Antibodies) promoter methylation may be the main mechanism leading to the low expression of PTEN and p16 (show CDKN2A Antibodies) genes indicating the progress of tumor development.

  5. Upon arsenite exposure of cells, over-expression of miR (show MLXIP Antibodies)-21 inhibits PTEN and activates ERK (show EPHB2 Antibodies), which is involved in arsenite-induced autophagy.

  6. Among advanced lung adenocarcinoma patients treated with platinum-based chemotherapy, the carriers of homozygous PTEN SNPS rs701848 and rs11202592 had significantly worse overall survival than heterozygotes or wild-type homozygotes, especially in stage III. Haplotype analysis revealed a protective effect of the haplotype G-A-A (in the order of rs11202592, rs701848, and rs11202607) on chemotherapy efficacy and survival.

  7. Low PTEN expression is associated with testicular germ cell tumor.

  8. Deleterious Non-Synonymous Single Nucleotide Polymorphisms in the PTEN Gene is associated with breast cancer.

  9. High PTEN expression is associated with drug resistance in ovarian cancer.

  10. Cowden syndrome, the principal PTEN-related disorder is characterized by multiple neoplasms and hamartomas, mucosal papillomatosis, and skin lesions, trichilemmomas[review]

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN, FOXO3A (show FOXO3 Antibodies) and PKB (show AKT1 Antibodies) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. miR (show MYLIP Antibodies)-26b participates in the inflammatory response of LPS (show IRF6 Antibodies)-stimulated bAMs by modulating the NF-kappaB (show NFKB1 Antibodies) pathway through targeting PTEN.

  2. Pten expression levels in the mammary glands of dairy cows, was investigated.

  3. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (show NOS3 Antibodies) activation in vascular endothelial cells.

  4. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  5. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (show DVL2 Antibodies).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN Antigen Profile

Antigen Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) antibody
  • phosphatase and tensin homolog (PTEN) antibody
  • phosphatase and tensin homolog (pten) antibody
  • 10q23del antibody
  • 2310035O07Rik antibody
  • A130070J02Rik antibody
  • AI463227 antibody
  • B430203M17Rik antibody
  • BZS antibody
  • CWS1 antibody
  • DEC antibody
  • GLM2 antibody
  • MHAM antibody
  • Mmac antibody
  • MMAC1 antibody
  • PTEN1 antibody
  • PTENP1 antibody
  • TEP1 antibody

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis
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