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PTEN antibody (AA 306-335)

PTEN Reactivity: Human IF, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032200
$578.58
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  • Target See all PTEN Antibodies
    PTEN (Phosphatase and Tensin Homolog (PTEN))
    Binding Specificity
    • 20
    • 20
    • 19
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 306-335
    Reactivity
    • 65
    • 24
    • 21
    • 7
    • 5
    • 3
    • 3
    • 3
    Human
    Host
    • 63
    • 2
    Rabbit
    Clonality
    • 62
    • 3
    Polyclonal
    Conjugate
    • 50
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTEN antibody is un-conjugated
    Application
    • 28
    • 23
    • 21
    • 17
    • 14
    • 13
    • 13
    • 8
    • 5
    • 3
    • 2
    • 2
    Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Xenopus
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 306-335 from the human protein was used as the immunogen for this PTEN antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PTEN (Phosphatase and Tensin Homolog (PTEN))
    Alternative Name
    PTEN (PTEN Products)
    Synonyms
    2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, MMAC1 antibody, TEP1 antibody, Mmac antibody, PTENP1 antibody, 10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, PTEN1 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, Pten antibody, PTEN antibody, pten.L antibody
    Background
    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
    UniProt
    P60484
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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