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Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) through PI3 kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 (show PPARG Proteins) regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
miR (show MLXIP Proteins)-152 controls both the expression of 14-3-3beta and HLA-G (show HLAG Proteins) and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT (show PARP1 Proteins), APAF1 (show APAF1 Proteins), BCL2 (show BCL2 Proteins), BAD, BID (show BID Proteins), MCL1 (show MCL1 Proteins), BIRC4 (show XIAP Proteins), BCL2L1 (show BCL2L1 Proteins), ENDOG (show ENDOG Proteins), YWHAB, and YWHAQ (show YWHAQ Proteins), influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c (show MYO1C Proteins)/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin (show INS Proteins)-stimulated glucose uptake.
Data identified three classes of 14-3-3 (show YWHAQ Proteins) targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
14-3-3beta binding to phosphorylated CFTR (show CFTR Proteins) augments its biogenesis by reducing retrograde retrieval of CFTR (show CFTR Proteins) to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR (show CFTR Proteins) available for anion secretion.
Data identified 14-3-3beta as a prognostic biomarker.
Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R (show CNR1 Proteins)).
SelW (show SEPW1 Proteins) enhances myoblast differentiation by inhibiting TAZ (show TAZ Proteins) binding to 14-3-3 (show YWHAQ Proteins).
Studies suggest that insulin (show INS Proteins) may modulate the cellular function of lipin-1 (show LPIN1 Proteins) by regulating its subcellular localization through interactions with 14-3-3 (show YWHAQ Proteins) proteins.
14-3-3 (show YWHAQ Proteins) participates in the intracellular trafficking of IRS-1 (show IRS1 Proteins)
The transcription start site was identified and the polyadenylation signals (AATAAA) were found in exon 2 of the mouse gene. In the 5'-upstream sequence, we found three cis (show CISH Proteins) elements including a CRE sequence, a TATA box-like sequence, and a C/EBP (show CEBPA Proteins) element.
PRAS40 (show AKT1S1 Proteins) is a novel substrate of Akt (show AKT1 Proteins), the phosphorylation of which leads to the binding of this protein to 14-3-3 (show YWHAQ Proteins).
14-3-3beta is a p90 (show GPAM Proteins) ribosomal S6 kinase (show RPS6KB1 Proteins) (RSK (show RPS6KA1 Proteins)) isoform 1-binding protein that negatively regulates RSK (show RPS6KA1 Proteins) kinase activity
14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo.
These results indicate for the first time that 14-3-3 protein (show YWHAE Proteins) plays a critical anti-apoptotic role in diabetic myocardium by inhibiting the JNK (show MAPK8 Proteins) pathway.
aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 (show NEDD4L Proteins) to block its interaction with ENaC (show SCNN1A Proteins), thus enhancing sodium absorption by increasing apical membrane ENaC (show SCNN1A Proteins) density
Data show that two members of Par (show AFG3L2 Proteins) proteins, 14-3-3 (Par-5 (show YWHAZ Proteins)) and atypical PKC (aPKC), regulate the serine/threonine kinase Par-1 (show F2R Proteins) to control Xenopus gastrulation
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
, 14-3-3 protein beta/alpha
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
, 14-3-3 alpha
, brain protein 14-3-3, beta isoform
, protein 1054
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
, 14-3-3 protein beta
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
, 14-3-3 protein beta-subtype
, 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
, prepronerve growth factor RNH-1
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide
, 14-3-3 protein beta/alpha-A
, 14-3-3-like protein