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Human AOC3 Protein expressed in Wheat germ - ABIN1345218
Ma, Manaenko, Khatibi, Chen, Zhang, Tang: Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011
This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response.
The mechanism of the Siglec-9 and AOC3 interaction
psoriatic patients with the dominant AT1R-A1166C polymorphism had significantly higher serum levels of VAP-1 and MDA but lower total bilirubine, uric acid, ARE, SOD and CAT activities compared to the corresponding control group
These findings suggest that vaspin (show SERPINA12 Proteins) and VAP-1 may play a role in the pathogenesis of psoriasis and can be used as markers of the disease
Our results show that colorectal myofibroblasts, as defined by the expression of AOC3 (show AOC2 Proteins), NKX2-3 (show NKX2-3 Proteins), and other markers, are a distinctly different cell type from TGFbeta (show TGFB1 Proteins)-activated fibroblasts
In this article, we will review the general characteristics and biological functions of VAP-1, focusing on its important role as a prognostic biomarker in human pathologies. [review]
serum VAP-1 can predict ESRD and is a useful biomarker to improve risk stratification in type 2 diabetic subjects.
Higher serum VAP-1 and Chronic kidney disease can independently predict future development of cancers in type II diabetic subjects
Complexes of human ORP2 and VAPs at endoplasmic reticulum-lipid droplet interfaces regulate the hydrolysis of triglycerides and lipid droplet turnover.
these results link the amine oxidase activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD and other chronic fibrotic liver diseases.
The lysine-rich protein soluble elastin (show ELN Proteins) bound to the enzyme tightly, which may have relevance to the reported roles of copper-containing quinoenzyme semicarbazide-sensitive amine oxidase in maintaining the extracellular matrix and in maturation of elastin (show ELN Proteins)
data indicate that SSAO inactivation in vivo stabilizes the established plaques mainly via inducing the switch of SMCs from a contractile to a synthetic phenotype
Suggest inhibiting VAP-1/SSAO enzymatic function, by PXS-4728A, as a novel therapeutic approach in lung diseases that are characterized by neutrophilic pattern of inflammation.
these results suggest a largely redundant function for AOC3/VAP-1 in allergic inflammatory responses of the airways.
The results of the study establish VCAM-1 (show VCAM1 Proteins) and VAP-1 as mediators of myeloid cell recruitment in metastasis and identify VAP-1 as a potential target for therapeutic intervention to combat early metastasis.
The antihyperglycemic effect of benzylamine is abolished by AOC3 gene knockout in mice.
Long-term activation of semicarbazide-sensitive amine oxidase by benzylamine lowers circulating levels of uric acid in diabetic conditions.
AOC3 expression is increased in perigonadal and subcutaneous adipose tissue of diabetic db-/- obese mice.
This review examines the biological functions of VAP-1, especially the role that this molecule might play in the establishment and progression of chronic liver disease.
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
amine oxidase, copper containing 3 (vascular adhesion protein 1)
, copper amine oxidase
, membrane primary amine oxidase
, placenta copper monamine oxidase
, semicarbazide-sensitive amine oxidase
, primary amine oxidase, liver isozyme
, serum amine oxidase
, amine oxidase, copper containing 3
, vascular adhesion protein 1
, copper containing amine oxidase 3
, primary amine oxidase, lung isozyme
, SEC31-like 1
, SEC31-like protein 1
, SEC31-related protein A
, protein transport protein Sec31A
, vesicle associated protein
, vesicle-associated protein 1