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Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1 (show SMARCA4 Proteins).
identified and characterized human HES (show RRBP1 Proteins)-like (HESL), rat hesl, and rainbow trout hesl genes by using bioinformatics
the combination of gain- and loss-of-function experiments in the developing midbrain showed co-operative roles for Mgn and Mash1 (show ASCL1 Proteins) genes in determining GABAergic identity.
the prethalamic factors Dlxs upregulated by Ascl1 (show ASCL1 Proteins)/Helt deficiency play unique roles in regulating thalamic progenitor specification.
Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity
identification of a novel mouse bHLH factor, termed Heslike, that has Hes1-like bHLH domain and transcriptional repressor activity; Heslike is coexpressed with the bHLH factor Mash1 (show ASCL1 Proteins) in brain regions that give rise to GABAergic neurons
Mgn is a single copy gene on mouse chromosome 8 and encodes a 27kDa (show HSPB1 Proteins) protein that functions in the nucleus.
Homozygous Mgn-null mice die between the second and the fifth postnatal week of age, and show a complete depletion of Gad65 (show GAD2 Proteins) and Gad67 (show GAD1 Proteins) expression in the superior colliculus and a reduction in the inferior colliculus.
Helt determines GABAergic over glutamatergic fate, by repressing Ngn (show NEUROG1 Proteins) genes; Helt and Ngns are commonly used in the mesencephalon for determination of the GABAergic versus glutamatergic transmitter phenotype.
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By similarity).
HES/HEY-like transcription factor
, Hey-like transcription factor
, Hey-like transcriptional repressor
, Megane bHLH factor
, hairy and enhancer of split-related protein HELT
, bHLH transcription factor megane
, mesencephalic GABAergic neurons enhancer of split related protein
, protein megane
, HES/HEY-like transcription factor, pseudogene 1
, Her/Hey-like protein
, hairy and enhancer of split-related protein helt