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our data highlight that NPW modulates the CaV1.2 (show CACNA1C ELISA Kits) currents via G protein-coupled receptor 7 (show NPBWR1 ELISA Kits), and the presence of it influences arterial tone.
these studies indicated an inconsistency between plasma and gastric NPW expression in response to nutrient ingestion, suggesting food induced gastric NPW expression may play a more important role locally
This review of NPW suggests that study of effects of this peptide may reveal its role in regulating feeding and energy metabolism coupled to leptin (show LEP ELISA Kits) levels in the brain.
Intracerebroventricular administration of NPW23 and NPW30 to free-feeding rats suppressed dark phase and fasting-induced (show C10orf10 ELISA Kits) food intake. Possibly NPW functions as an endogenous catabolic signaling molecule in the brain.
determined that non-AUG translation initiation is used to express human prepro-NPW
a non-AUG translation initiation site is used to express mouse prepro-Npw
These results indicate that the NPW/NPBWR1 (show NPBWR1 ELISA Kits) system could play a critical role in the gating of stressful stimuli during exposure to novel environments.
These findings suggest that the physiological role of NPW varies depending on the age of the mice.
These data suggest that the dorsomedial hypothalamus neurons that transiently co-express NPW and NPY (show NPY ELISA Kits) in the peri (show POSTN ELISA Kits)-weaning period might play a role in regulating energy homeostasis during postnatal development.
Neuropeptide W modulates gastric vagal afferent activity
Study indicates that NPW may play an important role in the regulation of feeding and energy metabolism.
a non-AUG translation initiation site is used to express the mouse Npw preproprotein (show CRH ELISA Kits)
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog.
, prepro-neuropeptide W
, preproprotein L8
, prepro-Neuropeptide W polypeptide
, prepro-neuropeptide W polypeptide