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anti-Human GNA11 Antibodies:
anti-Mouse (Murine) GNA11 Antibodies:
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Human Polyclonal GNA11 Primary Antibody for WB - ABIN1881378
Gavard, Gutkind: Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. in The Journal of biological chemistry 2008
Show all 6 Pubmed References
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (show SOX10 Antibodies) expression and presence of the BRAF (show BRAF Antibodies) V600E mutation.
Mutations in GNAQ (show GNAQ Antibodies) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (show GNAQ Antibodies), GNA11, and EIF1AX (show EIF1AX Antibodies) mutations.
GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.
CGRP (show S100A12 Antibodies) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS Antibodies), Galphai, and Galphaq (show GNAQ Antibodies)/11 pathways.
The identified GNA11 mutation results in biochemical abnormalities typical for autosomal dominant hypocalcemia. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation.
In 33 CASR (show CASR Antibodies)-negative patients with suspected FHH (show CASR Antibodies), Data found two (~6%) with a mutation in AP2S1 (show AP2S1 Antibodies) (p.Arg15Leu and p.Arg15His). Family screening confirmed the genotype-phenotype correlations. Data did not identify any pathogenic mutations in GNA11.
Driver mutations are rare in mutational hotspots of BRAF (show BRAF Antibodies), NRAS (show NRAS Antibodies), KIT, and GNAQ (show GNAQ Antibodies)/GNA11 in oral mucosal melanoma.
These findings demonstrate that CaSR (show CASR Antibodies)-targeted compounds can rectify signaling disturbances caused by germline and somatic Galpha11 mutations, which respectively lead to calcium disorders and tumorigenesis; and that ADH2 (show ADH1B Antibodies)-causing Galpha11 mutations induce non-constitutive alterations in MAPK (show MAPK1 Antibodies) signaling.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (show GNAQ Antibodies)/11-dependent fashion.
claudin-3 (show CLDN3 Antibodies) and claudin-5 (show CLDN5 Antibodies) expression is increased by DHEAS (show SULT2A1 Antibodies) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (show GNAQ Antibodies)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (show OPN4 Antibodies) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (show GNAQ Antibodies)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 Antibodies))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 Antibodies), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 Antibodies)-induced stimulation of Erk1/2 (show MAPK1/3 Antibodies), ATF-1 (show AFT1 Antibodies), and CREB (show CREB1 Antibodies).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (show MAPK1 Antibodies) cascade via the Galpha(q (show GNAQ Antibodies)/11)--p63RhoGEF--RhoA (show RHOA Antibodies) axis.
Myocytes from the Galpha(q (show GNAQ Antibodies)) and/or Galpha (show SUCLG1 Antibodies)(11) KO mice displayed genuine alterations in the action potentials, membrane capacitance, membrane currents, and Ca(2 (show CA2 Antibodies)+) handling
Report differential expression of protein kinase C (show PKC Antibodies) isoforms in coronary arteries of diabetic mice lacking Gna11.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit