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The nude mice xenograft model demonstrated that ectopic expression of the B3GNT7 gene in colon cancer cells diminished the migration capability and the liver-metastasis potential, respectively, of colon cancer cells.
sulfated (show SULF1 Proteins) keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues
May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues (By similarity).
, beta 1,3-N-acetylglucosaminyltransferase 7
, beta-1,3-N-acetylglucosaminyltransferase 7
, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like