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genomic organization and mapping of beta 4GalT-VIb (show SEMA6B ELISA Kits) to human chromosome 18q12.1
lactosylceramide (LacCer) synthesized by beta-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system during chronic experimental autoimmune encephalomyelitis, a model of multiple sclerosis.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
, beta-1,4-GalTase 6
, beta-1,4-galactosyltransferase 6
, beta-1, 4-galactosyltransferase VI