Browse our anti-Heparanase (HPSE) Antibodies

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anti-Heparanase Antibodies (HPSE)
On are 194 Heparanase (HPSE) Antibodies from 23 different suppliers available. Additionally we are shipping Heparanase Kits (46) and Heparanase Proteins (28) and many more products for this protein. A total of 273 Heparanase products are currently listed.
Hep, Hpa, HPA1, Hpr1, HPSE, HPSE1, HSE1, im:7144134

Most Popular Reactivities for anti-Heparanase (HPSE) Antibodies

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All available anti-Heparanase Antibodies

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Top referenced anti-Heparanase Antibodies

  1. Human Polyclonal HPSE Primary Antibody for IHC (fro), IHC (p) - ABIN1450178 : Vlodavsky, Friedmann, Elkin, Aingorn, Atzmon, Ishai-Michaeli, Bitan, Pappo, Peretz, Michal, Spector, Pecker: Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. in Nature medicine 1999 (PubMed)
    Show all 8 references for 1450178

  2. Human Monoclonal HPSE Primary Antibody for ICC, FACS - ABIN438793 : Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009 (PubMed)
    Show all 2 references for 438793

  3. Human Polyclonal HPSE Primary Antibody for EIA, IHC (fro) - ABIN1107505 : Navarro, Fares, Sanchez, Nadam, Georges, Moulin, Morales, Pequignot, Bezin: Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. in Journal of neurochemistry 2008 (PubMed)

More Antibodies against Heparanase Interaction Partners

Human Heparanase (HPSE) interaction partners

  1. The heparanase/syndecan1 (show SDC1 Antibodies) axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.

  2. Results show that HPSE is upregulated in human glioma and seems to confer a growth advantage on glioma cells.

  3. under physiological pH and low levels of tissue factor (show F3 Antibodies), heparanase may exert a non-enzymatic function interacting and activating the inhibitory function of antithrombin (show SERPINC1 Antibodies).

  4. Heparanase has emerged as a major regulator of cancer by degrading heparan sulfate thereby influencing multiple signaling pathways that control gene expression, syndecan (show SDC1 Antibodies) shedding and cell behavior. (Review)

  5. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 (show HPSE2 Antibodies) a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 (show ITGA2 Antibodies) a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects.

  6. heparanase activity is increased without changes in superoxide dismutase (show SOD1 Antibodies) activity in the granulocytes from patients with lupus nephritis and membranous nephropathy

  7. Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (show F3 Antibodies) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (show TFPI Antibodies)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (show TFPI Antibodies) and resulting in increased cell surface coagulation activity. [review]

  8. Heparanase procoagulant activity predicts post-surgery necrosis.

  9. Suggest heparanase is a promising, novel target for overcoming myeloma resistance to therapy and that targeting heparanase has the potential to prevent relapse in myeloma and possibly other cancers.

  10. expression of BRMS1 (show BRMS1 Antibodies) and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma

Mouse (Murine) Heparanase (HPSE) interaction partners

  1. eNOS (show NOS3 Antibodies) prevents heparanase induction and the development of proteinuria

  2. Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 Antibodies)) facilitated the release of vascular endothelial growth factor C (VEGF-C (show VEGFC Antibodies)) from SDC-1 (show SDC1 Antibodies)/VEGF-C (show VEGFC Antibodies) complex into the medium of hepatocarcinoma cell.

  3. the activation of intestinal heparanase contributes to intestinal injury during early sepsis by facilitating the destruction of mucosal epithelial glycocalyx and promoting inflammatory responses.

  4. Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE (show AGER Antibodies)-NF-kappaB (show NFKB1 Antibodies) pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.

  5. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  6. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Antibodies) and MAPK P38 (show MAPK1 Antibodies) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  7. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Antibodies).

  8. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Antibodies)) and -beta-D-glucuronidase (show GUSB Antibodies) heparanase (HPSE).

  9. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  10. Studies in heparanase-deficient mice established its contributions to autophagy.

Pig (Porcine) Heparanase (HPSE) interaction partners

  1. These data suggest that porcine reproductive and respiratory syndrome virus activates NF-kappaB (show NFKB1 Antibodies) and cathepsin L (show CTSL Antibodies) to upregulate and process heparanase, and then the active heparanase cleaves heparan sulfate, resulting in viral release.

  2. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  3. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 (show HPSE2 Antibodies) genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 (show HPSE2 Antibodies) mRNA did not induce a prominent change in PAMs

  4. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  5. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) interaction partners

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (show LHB Antibodies) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Antigen Profile

Antigen Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Heparanase (HPSE)

  • heparanase (HPSE) antibody
  • heparanase (hpse) antibody
  • heparanase (Hpse) antibody
  • heparanase (LOC100101601) antibody
  • Hep antibody
  • Hpa antibody
  • HPA1 antibody
  • Hpr1 antibody
  • HPSE antibody
  • HPSE1 antibody
  • HSE1 antibody
  • im:7144134 antibody

Protein level used designations for anti-Heparanase (HPSE) Antibodies

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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