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Overexpression or silencing of HS6ST2 significantly enhanced or abrogated the effects of fibroblast growth factor (FGF)2 (show FGF2 Proteins) on chondrocyte growth, respectively.
Hs6st2 knockout mice had increased body weight, insulin (show INS Proteins) resistance and high thyroid hormone (show PTH Proteins) level.
both HS6ST-1 (show HS6ST1 Proteins) and HS6ST-2 are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase (show TPSAB1 Proteins)
Results indicate that HS6ST2 gene influences expression of genes linked to aggrecan (show ACAN Proteins) metabolism and is implicated in pathogenesis of osteoarthritis.
6OST2 is more mesenchymal than its isoenzymes during development
Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated (show SULF1 Proteins) and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
HS6ST-1 (show HS6ST1 Proteins) and HS6ST-2 have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF (show HBEGF Proteins) signaling and subsequent expression of angiogenic cytokines by cancer cells
HS6ST2 knockdown disrupts epithelial-mesenchymal transition and suggesets that HS6ST2 potentiates Notch (show NOTCH1 Proteins) signaling in pancreatic cancer cells.
we have characterized HS6ST-2 and HS6ST-1 (show HS6ST1 Proteins) human isologues, including their chromosomal localizations,HS6STs could also transfer sulfate to N -sulfoglucosamine residues located at the non-reducing terminal of HS with high affinity.
hs6st2 is required for the branching morphogenesis of the caudal vein during embryonic development.
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.
heparan sulfate 6-O-sulfotransferase 2
, heparan-sulfate 6-O-sulfotransferase 2
, heparan-sulfate 6-O-sulfotransferase 2-like
, heparan sulfate 6-O-sulfotransferase-2
, HS 6-OST-2