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Browse our Syndecan 2 Proteins (SDC2)

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Syndecan 2 Proteins (SDC2)
On are 11 Syndecan 2 (SDC2) Proteins from 5 different suppliers available. Additionally we are shipping Syndecan 2 Antibodies (61) and Syndecan 2 Kits (12) and many more products for this protein. A total of 88 Syndecan 2 products are currently listed.
4833414L08Rik, AA960457, cb440, CD362, HSPG, Hspg1, Synd2, syndecan-2, zgc:103676
list all proteins Gene Name GeneID UniProt
SDC2 6383 P34741
SDC2 15529 P43407
SDC2 25615 P34900

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Syndecan 2 Proteins (SDC2) by Origin

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More Proteins for Syndecan 2 Interaction Partners

Zebrafish Syndecan 2 (SDC2) interaction partners

  1. Results uncover a novel Sdc2-Tbx16-Fgf2 (show FGF2 Proteins) pathway that regulates epithelial cell morphogenesis.

  2. We show here that sdc2,sdc3 (show SDC3 Proteins) and sdc4 (show SDC4 Proteins) are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.

  3. Syndecan-2 is essential for angiogenic sprouting during zebrafish development

  4. Data show that syndecan 2 expressed in the extra-embryonic yolk syncytial layer acts locally at the YSL-embryo interface to direct organ primordia migration, and is required for fibronectin (show FN1 Proteins) and laminin matrix assembly throughout the embryo.

Human Syndecan 2 (SDC2) interaction partners

  1. SDC2 is overexpressed in Leri's pleonosteosis. The minor allele of a missense SDC2 variant, p.Ser71Thr, could confer protection against systemic sclerosis.

  2. In this review we considered the function of syndecan-2, the structure of syndecan-2 and its role in the formation of amyloid plaques.

  3. HIV matrix protein p17 (show PDE6D Proteins) is pro-fibrogenic through its interactions both with CXCR2 (show CXCR2 Proteins) and syndecan-2 on activated HSCs

  4. The results demonstrate the importance of PDZ-binding domain of syndecan-2 for controlling LFA-1 (show ITGAL Proteins) affinity and cell adhesion.

  5. SDC2 expression was higher in skin melnaoma cells. It enhanced tyrosinase activity by increasing the membrane and melanosome localization of protein kinase CbetaII. UVB-induced up-regulation was required for UVB-induced melanin synthesis.

  6. syndecan 2 shows no changes associated to histological grade of Prostate cancer

  7. RhoA (show RHOA Proteins), but not RhoC (show RHOC Proteins) was shown to be essential for the anchored phenotype of breast carcinoma cells that accompanied siRNA-mediated loss of syndecan-2.

  8. RKIP (show PEBP1 Proteins), LOX (show LOX Proteins) and SDC2 are coordinately regulated and collectively encompass a prognostic signature for metastasis-free survival in ER-negative breast cancer patients

  9. Taken together, these data suggest that IL-1alpha regulates extracellular domain shedding of syndecan-2 through regulation of the MAP kinase (show MAPK1 Proteins)-mediated MMP-7 (show MMP7 Proteins) expression in colon cancer cells.

  10. Clinical validation of SDC2 methylation in serum DNA by quantitative methylation-specific PCR demonstrated a high sensitivity of 87.0% (95% CI, 80.0% to 92.3%) in detecting cancers.

Mouse (Murine) Syndecan 2 (SDC2) interaction partners

  1. In mouse melanoma cells, siRNA-mediated knockdown of syndecan-2 was associated with reduced melanin synthesis, whereas overexpression of syndecan-2 increased melanin synthesis.

  2. The N-terminal growth-factor-like domain of amyloid-beta precursor protein is necessary for protein-receptor binding, whereas the E2-domain mediates interaction with membrane-anchored syndecan 2 and glypican 1 (show GPC1 Proteins).

  3. The repression of syndecan-2 by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/TCF (show HNF4A Proteins) signaling contributes to the resistance of osteosarcoma cells to doxorubicin.

  4. MC1R (show MSHR Proteins) regulates melanoma cell migration via inhibition of syndecan-2 expression.

  5. Sarm1 (show SARM1 Proteins), a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphogenesis.

  6. RGD-independent cell adhesion via a tissue transglutaminase (show TGM2 Proteins) 2 (show TGM2 Proteins)-fibronectin (show FN1 Proteins) matrix promotes fibronectin (show FN1 Proteins) fibril deposition and requires syndecan-4 (show SDC4 Proteins)/2 and {alpha}5{beta}1 integrin co-signaling.

  7. The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.

  8. Syndecan-2 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury.

  9. HSPG and LRP (show LRP1 Proteins) together participate in VLDL clearance by means of a synergistic relationship.

  10. syndecan-2 has a role in the integration of signals from soluble and insoluble factors

Syndecan 2 (SDC2) Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Alternative names and synonyms associated with Syndecan 2 (SDC2)

  • syndecan 2 (sdc2)
  • syndecan 2 (SDC2)
  • syndecan 2 (LOC100224966)
  • syndecan 2 (Sdc2)
  • 4833414L08Rik protein
  • AA960457 protein
  • cb440 protein
  • CD362 protein
  • HSPG protein
  • Hspg1 protein
  • Synd2 protein
  • syndecan-2 protein
  • zgc:103676 protein

Protein level used designations for Syndecan 2 Proteins (SDC2)

syndecan-2 , syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) , syndecan 2 , cell surface-associated heparan sulfate proteoglycan 1 , fibroglycan , heparan sulfate proteoglycan 1, cell surface-associated , heparan sulfate proteoglycan core protein , syndecan proteoglycan 2 , HSPG , heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan) , Ryudocan/syndecan 2 , SYND2

282667 Danio rerio
374102 Gallus gallus
477945 Canis lupus familiaris
549917 Xenopus (Silurana) tropicalis
100224966 Taeniopygia guttata
6383 Homo sapiens
15529 Mus musculus
25615 Rattus norvegicus
615785 Bos taurus
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