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Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened
Localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of olfactory and lens placodes.
This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD.
HHIP expression and Gli1 (show GLI1 Proteins) expression were independent prognostic factors in glioblastoma.
HHIP - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.
Shh (show SHH Proteins)-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh (show SHH Proteins) signaling.
HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease.
HHIP is located within genes previously associated with chronic obstructive pulmonary disease susceptibility.
Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease.
The data demonstrated that loss of expression of HHIP and PTCH (show PTCH1 Proteins) is associated with the methylation of gene promoters
We show that GPC3 (show GPC3 Proteins), an hepatocellular carcinoma biomarker and Hh mediator, regulates human stellate cell viability by regulating Hh signaling.
Data indicate that the Shh (show SHH Proteins) signaling transduction is facilitated by binding of Shh (show SHH Proteins) to its receptor protein, Ptch (show PTCH1 Proteins), and show the complex structure of Shh (show SHH Proteins)-Hhip.
The HHIP gene that is known to be associated with stature in humans was strongly associated with direct calving difficulty in the present study.
PTCH1 (show PTCH1 Proteins), PTCH2 (show PTCH2 Proteins) and HHIP1 all contribute to ligand-dependent antagonism of sonic hedgehog (show SHH Proteins) signaling.
Estradiol improves the recovery of injured nerves by downregulating the Shh (show SHH Proteins) inhibitor hedgehog-interacting protein and increasing Shh (show SHH Proteins)-induced angiogenesis.
hedgehog (show SHH Proteins) antagonists patched 1 (show PTCH1 Proteins) and Hhip1 have roels in growth and pattern of the mammalian neural tube
hypothesis for a functional link between nitric oxide and Shh (show SHH Proteins) signaling and for a nonredundant role of Hip and Ptc1 (show PTCH1 Proteins) in the adult brain
These data indicate that Hh signaling plays a role in adult gut (show GUSB Proteins) epithelial homeostasis by regulating epithelial cell migration from crypt to villus tip and by enhancing apoptosis.
These results strongly suggest that GSK3beta phosphorylates Sufu (show SUFUH Proteins) to positively regulate Hedgehog (show SHH Proteins) signaling in mammalian cells.
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.
, hedgehog-interacting protein
, hedgehog interacting protein
, hedgehog-interacting protein-like
, Hedgehog-interacting protein-like