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Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) ELISA Kits (RNASEL)
On are 5 Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) ELISA Kits from 4 different suppliers available. Additionally we are shipping RNASEL Antibodies (66) and RNASEL Proteins (9) and many more products for this protein. A total of 82 RNASEL products are currently listed.
E230029I04Rik, PRCA1, RNS4
list all ELISA KIts Gene Name GeneID UniProt
Mouse RNASEL RNASEL 24014 Q05921
RNASEL 6041 Q05823

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Mouse (Murine) Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. RNAse L stimulates fibroblast migration.

  2. Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon (show IFNA ELISA Kits) but rather correlates with adequate levels of basal Oas (show SMOC1 ELISA Kits) gene expression, maintained by basal interferon (show IFNA ELISA Kits) signaling.

  3. Thus, RNA cleavage events catalyzed by RNase L are required for optimal inflammasome activation during viral infections.

  4. cellular functions of RNase L through protein-protein interactions in the spleen for immune response in mammals

  5. Data indicate that deficiency of 2-5A-dependent RNase L (RNase L) in resulted in a significant delay of diabetes onset.

  6. RNase L contributes to innate immunity through regulating macrophage functions.

  7. By targeting the effector enzyme of this antiviral pathway, L* potently inhibits RNase L, underscoring the importance of this enzyme in innate immunity against Theiler's virus.

  8. RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.

  9. These studies highlight novel roles of RNase L in cigarette smoke plus virus induced inflammation, tissue remodeling, apoptosis, and cytokine elaboration

  10. RNase L activation during mouse hepatitis virus infection is cell type specific and correlates with relatively high levels of expression of oligoadenylate synthetase genes, which are necessary for an effective RNase L antiviral response.

Human Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. We show that mutations in RNase L found in HPC patients may promote prostate cancer by increasing expression of AR-responsive genes and cell motility and identify novel roles of RNase L as a prostate cancer susceptibility gene.

  2. Suggest that naturally occurring mutations in the RNase L gene might promote enhanced prostate cancer cell migration and metastasis.

  3. This review outlines the role of RNase-L in antimicrobial immunity and the cytoskeleton-associated innate response. [review]

  4. Data show that RNA decay by ribonuclease L (RNase L) has an important role in homeostasis and serves as a suppressor of cell adhesion.

  5. Single Nucleotide Polymorphisms in RNASEL involved in the immune response are generally not associated with intraprostatic inflammation in men without a Prostate cancer diagnosis.

  6. OAS3 (show OAS3 ELISA Kits) displayed a higher affinity for dsRNA in intact cells than either OAS1 (show OAS1 ELISA Kits) or OAS2 (show OAS2 ELISA Kits), consistent with its dominant role in RNase L activation.

  7. Tanslation of vaccinia virus A27L and B5R (show CYB5R3 ELISA Kits) genes is independent of PKR (show PKLR ELISA Kits) activation, but their expression is dependent on the RNase L activity.

  8. Our results demonstrate a novel role of RNase L generated small RNAs in cross-talk between autophagy and apoptosis that impacts the fate of cells during viral infections and cancer.

  9. Among 794 RNASEL Ssingle nucleotide polymorphism (SNPs) entries 124 SNPs were found nonsynonymous (ns) from which SIFT predicted 13 nsSNPs as nontolerable whereas PolyPhen-2 predicted 28.

  10. Virus infection and RNase L activation disrupt its association with Filamin A (show FLNA ELISA Kits) and release RNase L to mediate its canonical nuclease (show DCLRE1C ELISA Kits)-dependent antiviral activities.

Pig (Porcine) Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. A 2.5 A and 3.25 A X-ray crystal and small-angle X-ray scattering structure of RNase L bound to a natural 2-5A activator with and without ADP or the nonhydrolysable ATP mimetic AMP (show TMPRSS5 ELISA Kits)-PNP (show NP ELISA Kits) is functionally characterized.

RNASEL Antigen Profile

Antigen Summary

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.

Alternative names and synonyms associated with RNASEL

  • ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) (Rnasel) Elisa Kit
  • ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (RNASEL) Elisa Kit
  • E230029I04Rik Elisa Kit
  • PRCA1 Elisa Kit
  • RNS4 Elisa Kit

Protein level used designations for RNASEL

2-5A-dependent RNAase , 2-5A-dependent RNase , 2-5A-dependent ribonuclease , RNase L , ribonuclease 4 , 2',5'-oligoisoadenylate synthetase-dependent , interferon-induced 2-5A-dependent RNase

24014 Mus musculus
6041 Homo sapiens
490310 Canis lupus familiaris
100048946 Sus scrofa
100048947 Bos taurus
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