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Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2 (show RLN1 ELISA Kits)) appears to be associated with increased ratio of BCL2 (show BCL2 ELISA Kits)/BAX (show BAX ELISA Kits) messenger RNA expression; thus, Ang II (show AGT ELISA Kits) and/or RLN2 (show RLN1 ELISA Kits) appear to be involved in regulation of apoptosis in prostate epithelium.
Relaxin (show 0 ELISA Kits) in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K (show PIK3CA ELISA Kits)-Akt (show AKT1 ELISA Kits) pathway.
a novel fusion transcript comprising the RLN1 (show RLN1 ELISA Kits) and RLN2 (show RLN1 ELISA Kits) genes, was identified.
The complex binding mode of the peptide hormone H2 relaxin (show 0 ELISA Kits) to its receptor RXFP1 (show RXFP1 ELISA Kits) has been deciphered.
Although serum relaxin (show 0 ELISA Kits) level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes (show PES1 ELISA Kits) planus suggest the hypothesis that relaxin (show 0 ELISA Kits) has a limited and indefinite role in patients with BJHS.
Relaxin (show 0 ELISA Kits) Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 (show TGFB1 ELISA Kits) Production and Mesangial Cells Phenotypic Transition
the correlation between RLN2 (show RLN1 ELISA Kits) and p-AKT (show AKT1 ELISA Kits) or RLN2 (show RLN1 ELISA Kits) and p-ERK1/2 (show MAPK1/3 ELISA Kits) expression was investigated.
Serum concentrations of relaxin (show 0 ELISA Kits) showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Effects of RLX (show RLN1 ELISA Kits) on the electrical properties of cardiac stromal cell membrane correlate well with its well-known ability to suppress myofibroblast differentiation, supporting the possibility that RLX (show RLN1 ELISA Kits) may be used for the treatment of cardiac fibrosis.
H2 relaxin (show 0 ELISA Kits) is fully active at the relaxin (show 0 ELISA Kits) receptor RXFP1 (show RXFP1 ELISA Kits) and thus dimerization is not required for biological activity.
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
, prorelaxin H2
, relaxin, ovarian, of pregnancy
, relaxin 2
, relaxin 3-like protein c
, relaxin 3c
, relaxin family locus X