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Browse our V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins (MAFA)

Full name:
V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins (MAFA)
On www.antibodies-online.com are 6 V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Proteins from 3 different suppliers available. Additionally we are shipping V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Antibodies (76) and many more products for this protein. A total of 87 V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) products are currently listed.
Synonyms:
2F1-Ag, hMafA, L-MAF, MAFA, MAFA-L, mafl, RGD1562627, RIPE3b1, SMaf1
list all proteins Gene Name GeneID UniProt
MAFA 50928 O88713
Rat MAFA MAFA 58975 Q64335
MAFA 389692 Q8NHW3

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V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins (MAFA) by Origin

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More Proteins for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Interaction Partners

Mouse (Murine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes.

  2. These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin (show INS Proteins) secretion and that loss of MaoB (show MAOB Proteins) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  3. is necessary for the maintenance of normal insulin (show INS Proteins) levels even in embryos.

  4. endogenous small-Maf (show MAF Proteins) factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf (show MAF Proteins) activity can improve beta-cell function

  5. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb (show MAFB Proteins) is specific to insulin (show INS Proteins)-secreting cells of the pancreas.

  6. These results suggest that MafA regulates the postnatal proliferation of beta-cells via prolactin (show PRL Proteins) signaling.

  7. This finding provides a rationale for the reciprocal expression of KLRG1 (show KLRG1 Proteins) and CD103 (show ITGAE Proteins) in different CD8 (show CD8A Proteins)(+) T-cell subsets.

  8. results illustrate how consequential the reduction in Mafa activity is to islet beta-cell function under pathophysiological conditions.

  9. Cytotoxic KLRG1 (show KLRG1 Proteins)-expressed CD8 (show CD8A Proteins) effector cells and defective T regulatory cells cause murine autoimmune cholangitis.

  10. KLRG1 (show KLRG1 Proteins)(+) iNKT cells coexpressing CD49d and granzyme A (show GZMA Proteins) persisted for several months and displayed a potent secondary response to cognate antigen.

Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. Pdx1 (show PDX1 Proteins) and MafA (show KLRG1 Proteins) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 (show PDX1 Proteins) and MafA (show KLRG1 Proteins) were significantly upregulated after a sleeve gastrectomy for morbid obesity.

  2. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in patients with type 2 diabetes.

  3. These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin (show INS Proteins) secretion and that loss of MaoB (show MAOB Proteins) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  4. MAFA (show KLRG1 Proteins), MAFB (show MAFB Proteins), NKX6.1 (show NKX6-1 Proteins), and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity

  5. Loss of MAFA (show KLRG1 Proteins) expression is associated with insulinoma (show RPS15 Proteins).

  6. MAFA (show KLRG1 Proteins) nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 (show PAX4 Proteins) are altered in patients with type 2 diabetes.

  7. under oxidative and nonoxidative conditions p38 MAPK (show MAPK14 Proteins) directly binds to MafA (show KLRG1 Proteins) and triggers MafA (show KLRG1 Proteins) degradation via ubiquitin proteasomal pathway.

  8. Beta cell nuclear MafA (show KLRG1 Proteins) is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

  9. Combined transfection of the three transcriptional factors, PDX-1 (show PDX1 Proteins), NeuroD1 (show NEUROD1 Proteins), and MafA (show KLRG1 Proteins), causes differentiation of bone marrow mesenchymal stem cells into insulin (show INS Proteins)-producing cells

  10. Data suggest that MafA (show KLRG1 Proteins) plays a novel role in the reprogramming of stem cells into pancreatic beta-progenitors, promotes the islet-like characteristics of PDMSCs, as well as functionally regulation of blood glucose levels in transplanted grafts.

V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Protein Profile

Protein Summary

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS\; MIM 176730) (Olbrot et al., 2002

Alternative names and synonyms associated with V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA)

  • killer cell lectin-like receptor subfamily G, member 1 (Klrg1)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafa)
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene A (Mafa)
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA)
  • v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) (Mafa)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) (mafa)
  • 2F1-Ag protein
  • hMafA protein
  • L-MAF protein
  • MAFA protein
  • MAFA-L protein
  • mafl protein
  • RGD1562627 protein
  • RIPE3b1 protein
  • SMaf1 protein

Protein level used designations for MAFA

killer cell lectin-like receptor subfamily G member 1 , mast cell function-associated antigen 2F1 , mast cell function-associated antigen , v-maf musculoaponeurotic fibrosarcoma oncogene homolog A , Transcription factor MafA , leucine zipper transcription factor , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A , pancreatic beta-cell-specific transcriptional activator , transcription factor MafA , transcription factor RIPE3b1 , Mafa homolog , V-maf musculoaponeurotic fibrosarcoma oncogene homolog A , bZIP transcription factor L-Maf , lens-specific Maf , somite Maf1 , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L

GENE ID SPECIES
50928 Mus musculus
58975 Rattus norvegicus
613050 Xenopus (Silurana) tropicalis
366949 Rattus norvegicus
389692 Homo sapiens
378435 Mus musculus
395881 Gallus gallus
100000492 Danio rerio
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